Abstract

Recent information obtained as a result of law enforcement activities in Portugal has indicated that a particular group of athletes is likely using caffeine in conjunction with oxandrolone. In this paper we present our work to investigate the possible effect of this co-administration. Therefore excretion studies were undertaken to determine what effects were produced and what their extent was. In these studies a single dose of oxandrolone was given, with and without the application of caffeine. A noticeable effect was observed upon both the clearance of oxandrolone and the metabolism to epioxandrolone. The concentration of both oxandrolone and epioxandrolone excreted in the urine increases substantially with caffeine intake. The results are discussed and assessed. Verf.-Referat