Erythropoiesis stimulating agents and techniques : a challenge for doping analysts
Gespeichert in:
| Deutscher übersetzter Titel: | Stimulanz-Wirkstoffe und Techniken der Erythropoese : Anknüpfungspunkte für Dopinganalytiker |
|---|---|
| Autor: | Jelkmann, Wolfgang |
| Erschienen in: | Current medicinal chemistrychemistry |
| Veröffentlicht: | 16 (2009), 10, S. 1236-1247, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 0929-8673, 1875-533X |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201007005529 |
| Quelle: | BISp |
| id |
PU201007005529 |
|---|---|
| bisp-collection |
db |
| format |
Literatur |
| last_indexed |
2010-07-20T08:21:22Z |
| first_indexed |
2010-07-20T07:53:06Z |
| publication_source |
BISp |
| subformat |
Zeitschriftenartikel |
| hierarchy_top_id |
JO00000100534 |
| hierarchy_parent_id |
JOI200900100100534 |
| hierarchy_top_title |
Current medicinal chemistrychemistry |
| hierarchy_parent_title |
Current medicinal chemistrychemistry, 2009, 10 |
| is_hierarchy_id |
PU201007005529 |
| is_hierarchy_title |
Erythropoiesis stimulating agents and techniques : a challenge for doping analysts |
| hierarchy_sequence |
1236 |
| recordtype |
bisparticle |
| publishDate |
2009 |
| publishDate_facet |
2009 |
| language |
eng |
| title |
Erythropoiesis stimulating agents and techniques : a challenge for doping analysts |
| spellingShingle |
Erythropoiesis stimulating agents and techniques : a challenge for doping analysts Blutdoping Doping Dopinganalyse Dopingbekämpfung Erythropoetin Hämatologie Protein Stimulans Tierversuch |
| title_sort |
erythropoiesis stimulating agents and techniques a challenge for doping analysts |
| title_short |
Erythropoiesis stimulating agents and techniques : a challenge for doping analysts |
| title_alt |
Stimulanz-Wirkstoffe und Techniken der Erythropoese : Anknüpfungspunkte für Dopinganalytiker |
| title_alt_lang |
deu |
| media_type |
Gedruckte Ressource |
| city |
Shiphol |
| abstract |
Recombinant human erythropoietin (rHuEPO) engineered in Chinese hamster ovary (CHO) cell cultures (Epoetin alfa and Epoetin beta) and its hyperglycosylated analogue Darbepoetin alfa are known to be misused by athletes. The drugs can be detected by isoelectric focusing (IEF) and immunoblotting of urine samples, because “EPO” is in reality a mixture of isoforms and the N-glycans of the recombinant products differ from those of the endogenous hormone. However, there is a plethora of novel erythropoiesis stimulating agents (ESAs). Since the originator Epoetins alfa and beta are no longer protected by patent in the European Union, rHuEPO biosimilars have entered the market. In addition, several companies in Asia, Africa and Latin America produce copied rHuEPOs for clinical purposes. While the amino acid sequence of all Epoetins is identical, the structure of their glycans differs depending on the mode of production. Some products contain more acidic and others more basic EPO isoforms. Epoetin delta is special, as it was engineered by homologous recombination in human fibrosarcoma cells (HT-1080), thus lacking N-glycolylneuraminic acid like native human EPO. ESAs under development include EPO fusion proteins, synthetic erythropoiesis stimulating protein (SEP) and peptidic (HematideTM, CNTO 528) as well as non-peptidic EPO mimetics. Furthermore, preclinical respectively clinical trials have been performed with small orally active drugs that stimulate endogenous EPO production by activating the EPO promoter (“GATA-inhibitors”: diazepane derivatives) or enhancer (“HIF-stabilizers”: 2-oxoglutarate analogues). The prohibited direct EPO gene transfer may become a problem in sports only in the future. Verf.-Referat |
| abstract_lang |
eng |
| abstract_type |
author |
| author2 |
Jelkmann, Wolfgang |
| author_facet |
Jelkmann, Wolfgang |
| author2-role |
Autor |
| author2-authorityid |
|
| author_author_facet |
Jelkmann, Wolfgang |
| author2-synonym |
|
| author2_hierarchy_facet |
0/Autor/ 1/Autor/Jelkmann, Wolfgang/ |
| issn |
0929-8673 1875-533X |
| spelling |
0929-8673 1875-533X 1319315-6 Blutdoping Doping Dopinganalyse Dopingbekämpfung Erythropoetin Hämatologie Protein Stimulans Tierversuch animal experiment blood doping doping doping analysis erythropoietin fight against doping hematology protein stimulant Dopingmittel Dopinganalytik EPO Eiweiss Plasmaprotein Maus Ratte Tierexperiment Eigenblutinfusion Eigenblutreinfusion autologous blood Erythropoiesis stimulating agents and techniques : a challenge for doping analysts PU201007005529 201007005529 |
| zdb |
1319315-6 |
| location_hierarchy_facet |
0/Niederlande/ |
| topic |
Blutdoping Doping Dopinganalyse Dopingbekämpfung Erythropoetin Hämatologie Protein Stimulans Tierversuch |
| topic_facet |
Blutdoping Doping Dopinganalyse Dopingbekämpfung Erythropoetin Hämatologie Protein Stimulans Tierversuch |
| topic_en |
animal experiment blood doping doping doping analysis erythropoietin fight against doping hematology protein stimulant |
| topic_en_facet |
animal experiment blood doping doping doping analysis erythropoietin fight against doping hematology protein stimulant |
| synonym |
Dopingmittel Dopinganalytik EPO Eiweiss Plasmaprotein Maus Ratte Tierexperiment Eigenblutinfusion Eigenblutreinfusion |
| synonym_en |
autologous blood |
| journal_facet |
Current medicinal chemistrychemistry |
| container_title |
Current medicinal chemistrychemistry |
| container_volume |
16 |
| container_issue |
10 |
| container_start_page |
S. 1236-1247 |
| has_references |
1 |
| institution |
BISp |
| journal_fac |
JO00000100534 |
| journal_year |
2009 |
| journal_issue |
10 |
| _version_ |
1791514595358146560 |
| score |
13,546012 |