Abstract

There is no agreement in effectiveness of corticosteroids and also the clinical guidelines are poor with respect to optimal timing, dosage and injection volume. It is also not possible to characterize the type of application (e.g. injection, inhalation, local or oral administration) related to urinary concentrations. In order to clearly evaluate and establish some criteria in relation with glucocorticosteroid administration, WADA accepted to support a research project over two years. After acceptance of Ethical Committee, synthetic glucocorticosteroids currently administered were tested on numerous volunteers. For each compound, existing administration modes were applied (single and multiple applications) and excretion kinetics and patterns, urinary concentrations were established. Moreover, urinary free and conjugated fractions were evaluated. Analyses were performed by LC-MSn as already published in the literature. The first results were obtained with the application of triamcinolone acetonide. Results for nasal and pulmonary inhalations, intramuscular, intra-articular and intradermal injections are presented. Aus dem Text (geändert)