Synthesis and characterization of a metabolite of tamoxifen
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| Deutscher übersetzter Titel: | Die Synthese und Bestimmung eines Metaboliten von Tamoxifen |
|---|---|
| Autor: | Gärtner, Peter; Hofbauer, Karin ; Gmeiner, Günter; Geisendorfer, Thomas |
| Erschienen in: | Recent advances in doping analysis (15) : Proceedings of the Manfred Donike Workshop ; 25th Cologne Workshop on Dope Analysis ; 25th February to 2nd March 2007 |
| Veröffentlicht: | Köln: Sportverl. Strauß (Verlag), 2007, S. 371-374, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201001000333 |
| Quelle: | BISp |
Abstract
The anti-estrogen Tamoxifen, generally used in the treatment of breast cancer, is listed as a doping substance on the WADA Prohibited List due to its selective estrogen receptor modulator capabilities. Treatment of the negative effects of anabolic androgenic steroid abuse is the rumoured reason for the ban of this substance. The structure of the main metabolite in urine has not been determined yet. GC-MS data suggested that hydroxymethoxytamoxifen is the most probable one. 4-Hydroxy-3- methoxytamoxifen has been successfully synthesized, but comparing this compound with a sample obtained from an excretion study, it could be shown that this compound was not the metabolite. Therefore, it was suggested that 3-hydroxy-4-methoxytamoxifen should be synthesized in order to compare this compound with the sample obtained from an excretion study. Einleitung (geändert)