Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism
Gespeichert in:
| Deutscher übersetzter Titel: | Große Unterschiede bei der Testosteronausscheidung bei koreanischen und schwedischen Männern sind mit einem UDP-Glukuronosyl Transferase 2B17 Polymorphismus verbunden |
|---|---|
| Autor: | Ekström, Lena; Jakobsson, Jenny; Garle, Mats; Rane, Anders |
| Erschienen in: | Recent advances in doping analysis (14) : Proceedings of the Manfred Donike Workshop ; 24th Cologne Workshop on Dope Analysis ; 4th to 9th June 2006 |
| Veröffentlicht: | Köln: Sportverl. Strauß (Verlag), 2006, S. 211-215, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201001000242 |
| Quelle: | BISp |
Abstract
The objective of the study was to evaluate the contribution of the UGT2B17 deletion polymorphism to the interethnic variation of testosterone/epitestosterone ratio. Urine from 122 Swedish and 74 Korean healthy men was analyzed for testosterone and epitestosterone glucuronides. The distribution of the natural logarithms of urinary testosterone concentrations showed a distinct bimodal patent in both groups, suggesting a monogenic inheritance. When the UGT2B17 genotypes were compared with urinary testosterone levels, all of the individuals homozygous for the UGT2B17 deletion genotype had no or negligible amounts of urinary testosterone. The deletion/deletion genotype was seven times more common in the Korean (66.7%) than the Swedish population (9.3%). These data are of great importance for the anti-doping test programs. Verf.-Referat