The effect of butea superba roxb., a Thai traditional medicine, on endogenous steroid levels in males

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Bibliographic Details
Title translated into German:Der Effekt von Butea superba Roxb., einem traditionellen thailändischen Medikament, auf endogene Steroidniveaus bei Männern
Author:Nimsoongnern, S.; Pinthong, D.; Plasen, S.; Wilairat, P.; Kusamran, T.; Anukarahanonta, T.
Published in:Recent advances in doping analysis (16) : Proceedings of the Manfred Donike Workshop ; 26th Cologne Workshop on Dope Analysis ; 24th to 29th February 2008
Published:Köln: Sportverl. Strauß (Verlag), 2008, S. 383-386, Lit.
Format: Publications (Database SPOLIT)
Publication Type: Compilation article
Media type: Electronic resource (online) Print resource
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Identification number:PU200909005112


Butea superba Roxb. (Red Kwao Krua), a herb in the family Papilionaceas, has been used as a traditional medicine for the promotion of physical strength. This communication reports the study on the effect of Butea superba Roxb. on endogenous steroid profile and LH (luteinizing hormone) from healthy male volunteers. After oral administration of ground Butea superba Roxb. root and tuber, twenty-four hour urines were collected and analysed for endogenous steroids by GC/MS. The amount of LH was also determined in the same sample by fluoroimmunoassay. The alteration in serum enzymes indicating liver and kidney functions were studied in order to evaluate the toxicity of this herb. Elevations of several endogenous steroids were observed after short term administration of Butea superba Roxb. Among these are androstendione, testosterone, estradiol and estriol. The concentration of the glucocorticosteroids, cortisol and tetrahydrocortisol, were unaffected. Slight increase in urinary LH was observed. No significant change in T/DHT, androsterone/etiocholanolone and T/estradiol ratios were observed. Implications from overall effects of Butea superba Roxb. is discussed. Verf.-Referat