Abstract

Der 26. Manfred Donike Workshop zur Dopinganalyse fand vom 24. bis 29. Februar 2008 in Köln statt. Der hier vorliegende Kongress-Band beinhaltet alle Vorträge sowie Posterpräsentationen der Teilnehmer. Die Autoren und ihre Beiträge sind: H.M.G. Pereira, M.C. Padilha, R.M.A. Bento, T.P. Cunha, N.A.G. Lascas, F.R. Aquino Neto: Analytical and logistic improvements for the doping control analysis at the 2007 Pan-American Games; R. Kazlauskas: WADA list; P. Van Eenoo, W. Van Thuyne, O. Pozo- Mendoza, K. Deventer, L. Lootens, P. Van Renterghem, F.T. Delbeke: Results of several (small) research projects at DoCoLab in 2007; M. Tsivou, D. Livadara, D.G. Georgakopoulos, M. Koupparis, J. Atta-Politou, CG. Georgakopoulos: Preservation of urine doping control samples - Preliminary results; K. Deventer, P. Van Eenoo, Guy Baele, O.J. Pozo, F.T. Delbeke: Stability study of thiazide diuretics; M. Thevis, M. Kohler, N. Schlörer, G. Fußhöller, W. Schänzer: Screening for quinolinone-derived selective androgen receptor modulators using GC-MS and LC-MS/MS; T. Kuuranne, A. Leinonen, W. Schänzer, M. Kamber, R. Kostiainen, M. Thevis: Aryl-propionamide-derived selective androgen receptor modulators: Liquid chromatographic-tandem mass spectrometric characterization of the in vitro synthesized metabolites for doping control purposes; S. Guddat, M. Thevis, A. Thomas, W. Schänzer: Rapid screening of polysaccharide based plasma volume expanders dextran and hydroxyethyl starch in human urine by liquid chromatography – tandem mass spectrometry; M.K. Parr, H. Geyer, M. Gütschow, N. Haenelt, G. Opfermann, M. Thevis, W. Schänzer: New steroids on the "supplement" market; J. Henninge, I. Hullstein, I. Liborg, M. Lindoe, P. Hemmersbach: Longitudinal monitoring of steroid profiles - Improvements to the analytical procedure; T. Kuuranne, K.-H. Pystynen, R. Kostiainen, A. Leinonen, M. Thevis, W. Schänzer: Metabolism of "new" anabolic steroids: Development of in vitro methodology in metabolite production and analytical techniques; L. Lootens, P. Van Eenoo, O.J. Pozo, P. Meuleman, G. Leroux-Roels, F.T. Delbeke: Validation of the metabolism of steroids in uPA+/+-SCID mice with humanized liver; J.P. Danaceau, M.S. Morrison, M.H. Slawson: Quantitative confirmation of testosterone and epitestosterone in human urine by LC-Q-ToF mass spectrometry for doping control; O.J. Pozo, W. Van Thuyne, P. Van Eenoo, K. Deventer, F.T. Delbeke: Direct quantification of steroid glucuronides by liquid chromatography tandem mass spectrometry; C.J. Walker, D.A. Cowan, V.H.T. James, J.C.Y. Lau, A.T. Kicman: Evaluation of the extent of urinary excretion of 19-norandrosterone in women and considerations regarding norethisterone administration; O.J. Pozo, P. Van Eenoo, K. Deventer, L. Lootens, S. Grimalt, J.V. Sancho, F. Hernandez, F.T. Delbeke: General guidelines for the CID fragmentation of 3-keto-anabolic steroids; W. Van Thuyne, P. Van Eenoo, W. Van Gansbeke, F.T. Delbeke: Implementation of DRS in doping control; U. Mareck, H. Geyer, U. Flenker, T. Piper, M. Thevis, W. Schänzer: Population based reference ranges and additional screening marker for the improvement of the detection of dehydroepiandrosterone misuse; T. Piper, U. Flenker, W. Schänzer: Determination of 13C/12C ratios of endogenous urinary steroids: Method validation, reference population and implication for doping control purposes; H.J. Tobias, G.L. Sacks, Y. Zhang, J.T. Brenna: Progress towards comprehensive 2d gas chromatography combustion isotope ratio mass spectrometry (GCxGCC-IRMS); U. Flenker, S. Lüdke, U. Güntner, W. Schänzer: Which factors control 13C/12C-ratios of urinary steroids?; Y. Zhang, H.J. Tobias, J.T. Brenna: Uniform isotopic standards for gas chromatography combustion isotope ratio mass spectrometry of steroids; T. Piper, U. Flenker, W. Schänzer: Determination of D/H ratios of endogenous urinary steroids: Method validation and first results; P. Hemmersbach, Y. Dehnes, F. Mikkelsen, A. Lund, A. Solheim, L. Stolan, M. Drange: Individual blood profiling - A means of improving the fight against doping; V. Agon, C.J. Howe, R. Kazlauskas, G.J. Trout: Aspects of the detection of insulin abuse in sport; A. Thomas, H. Geyer, M. Kamber, W. Schänzer, M. Thevis: Mass spectrometric determination of gonadotrophin-releasing hormone (GnRH) in human urine for doping control purposes by means of LC-ESI-MS/MS; C. Goebel, J. Simpson, D. Marinelli, C.J. Howe, G.J. Trout, R. Kazlauskas, D.J. Handelsman: Measurement of LH in urine. A test for doping?; M. Okano, A. Ikekita, M. Sato, S. Kageyama: Analysis of growth hormone-releasing peptides for doping control; M. Kohler, K. Püschel, D. Sakharov, A. Tonevitskiy, W. Schänzer, M. Thevis: Detection method for recombinant human growth hormone based on 2D-PAGE; E. Llop, R. Gutiérrez-Gallego, J. Segura, J. Mallorqui, J.A. Pascual: Glycan profiling discriminates between rEPO δ (Dynepo®, produced in human cells) and rEPO α/ß (produced in CHO cells); M. Kohler, C. Ayotte, P. Desharnais, U. Flenker, S. Lüdke, A. Lüdke, M. Thevis, E. Völker-Schänzer, W. Schänzer: Relative mobility values for the discrimination of endogenous and recombinant EPO on SDS gels; C. Reichel, R. Kulovics, V. Jordan, M. Watzinger, T. Geisendorfer: SDS-PAGE of recombinant and endogenous erythropoietins: benefits and limitations of the method for application in doping control; S.A. Appolonova, M.A. Dikunets, G.M. Rodchenkov: Indirect detection of rHuEPO and synacthen administration in human urine; G. Bican, V. Pop, R. Subaru, M. Lamor, I. Vajiala: Improved detection of banned doping substances by triple quadrupole LC/MS2 technique; G. Fußhöller, W. Schänzer, D. Krumwiede: Improved screening of anabolic steroids in human urine using a new GC-triple quadrupole mass spectrometer - Preliminary results -; P. Anielski: Disintegration of hair samples vs. methanol extraction - Influences on the analysis of anabolic steroids; M.A. Dikunets, SA. Appolonova, G.M. Rodchenkov: Comprehensive screening of urinary free fraction using HPLC-MS/MS; T. Sobolevsky, I. Kachala, S. Bolotov, G. Rodchenkov: Detection of L- and D-stereoisomers of methamphetamine in urine following derivatization with menthyl chloroformate; G. Sigmund, M. Thevis, A. Koch, S. Guddat, W. Schänzer: Methods for the detection of tuaminoheptane; E. Palonek, R. Rylin, M. Garle, G. Rasmanis: Screening for ß-blockers in urine with on-line extraction and LC-MSMS detection; J.O. Thömgren, F. Österwall, M. Garle: Stereoselective confirmation of amines by chiral derivatization and UPLC-MS/MS; M. Mazzarino, M.C. Braganò, S. Turi, F. Botrè: LC-ESI-MS/MS screening method for simultaneous detection in human urine of glucocorticoids, diuretics, some stimulants, some beta2-agonists, some beta-blockers, anti-oestrogens and new designer steroids; M. Vahermo, A. Leinonen, T. Suominen, T. Kuuranne, J. Yli-Kauhaluoma: Synthesis of mesocarb metabolites as reference compounds for doping analytics; R.E. Simoni, F.B. Scalco, L.N.L.F. Gomes, C.F. Arnaldo, T.M. Moutinho, J.F. Paulino, S.F. Silva, M.L.C. Oliveira, F.R. Aquino Neto: Screening for HES in human urine and possible application for dextran; V. Gougoulidis, G. Sigmund, U. Flenker, W. Schänzer: Determination of gamma-butyrolactone (GBL) -A tool for the detection of the administration of gamma-hydroxybutyric acid (GHB)-; M. Mazzarino, F. Botrè: Fast screening for the detection of HES and dextran; F. Oueslati, M. Maatki, Z. Osman,, H. Loueslati: Identification by LC-ESI-MS/MS of new clomifene metabolites in urine; T. Sobolevsky, E. Virus, E. Semenistaya, V. Kachala, I. Kachala, G. Rodchenkov: Orastan-A: Structural elucidation and detection in urine; M.C. Padilha, H.M.G. Pereira, P.F. Aguiar, C.M.A. Silva, F.R. de Aquino Neto: Improvement in detection of 3’OH-stanozolol in human urine using a new ion trap mass spectrometry system; S.C. Voss, U. Flenker, B. Majer, W. Schänzer: Stability tests for haematologic parameters in an anti-doping context; S. Lamon, N. Robinson, P.E. Sottas, H. Henry, M. Kamber, P. Mangin, M. Saugy: Possible origin of undetectable EPO in urine samples; J. Henninge, I. Hullstein, G. Hagelin, P. Hemmersbach: Identification of growth hormone releasing hexapeptide (GHRP-6) in an unknown pharmaceutical preparation; C. Goebel, GJ. Trout, R. Kazlauskas: Implementation of insulin analysis by ASDTL; Y. Dehnes, M. Borgen, M. Lönnberg, P. Hemmersbach: Shifted isoelectric profiles of endogenous erythropoietin possibly due to different physiological origin; F. Donati, F. Botrè: Using Advia 120 hematological analyzer as a fast screening method for HBOCs detection in human whole blood; A. Beotra, R.I. Madhusudhana, G. Sandeep, S. Jain, J.S. Sandhu: Detectability of glucocorticosteroid formulations available in Indian market following different routes of administration; V. Pop, G. Bican, M. Lamor: Flunisolide - Triamcinolone acetonide. MS differentiation in positive and in negative ionization mode. LC differentiation; R. Jazwiec, D. Kwiatkowska, A. Pokrywka, D. Stanczyk: Use of porous graphite packed columns in analysis of doping control samples for glucocorticosteroids; H. Kraiem, F. Oueslati, S.S. Ben Amor, N. Fenina, H. Loueslati: Structural elucidation of seven prednisolone metabolites by LC-ESI-MS/MS using a PGC column; S. Nimsoongnern, D. Pinthong, S. Plasen, P. Wilairat, T. Kusamran, T. Anukarahanonta: The effect of butea superba roxb., a Thai traditional medicine, on endogenous steroid levels in males. AGa und Inhaltsverzeichnis