N-3 polyunsaturated fatty acids do not affect cytokine response to strenuous exercise
Deutscher übersetzter Titel: | Omega-3-Fettsaeuren beeinflussen die Reaktion der Zytokine auf erschoepfende koerperliche Belastung nicht |
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Autor: | Toft, A.D.; Thorn, M.; Ostrowski, K.; Asp, S.; Moeller, K.; Iversen, S.; Hermann, C.; Soendergaard, S.R.; Pedersen, B.K. |
Erschienen in: | Journal of applied physiology |
Veröffentlicht: | 89 (2000), 6, S. 2401-2406, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 8750-7587, 0021-8987, 0161-7567, 1522-1601 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199912500753 |
Quelle: | BISp |
Abstract des Autors
The aim of the present study was to investigate whether fish oil supplementation was able to modulate the acute-phase response to strenuous exercise. Twenty male runners were randomized to receive supplementation (n=10) with 6.0 g fish oil daily, containing 3.6 g n-3 polyunsaturated fatty acids (PUFA), for 6 wk or to receive no supplementation (n=10) before participating in The Copenhagen Marathon 1998. Blood samples were collected before the race, immediately after, and 1.5 and 3 h postexercise. The fatty acid composition in blood mononuclear cells (BMNC) differed between the fish oil-supplemented and the control group, showing incorporation of n-3 PUFA and less arachidonic acid in BMNC in the supplemented group. The plasma levels of tumor necrosis factor-alpha, interleukin-6, and transforming growth factor-beta1 peaked immediately after the run, the increase being 3-, 92-, and 1.1-fold, respectively, compared with resting samples. The level of interleukin-1 receptor antagonist peaked 1.5 h after exercise, with the increase being 87-fold. However, the cytokine levels did not differ among the two groups. Furthermore, supplementation with fish oil did not influence exercise-induced increases in leucocytes and creatine kinase. In conclusion, 6 wk of fish oil supplementation had no influence on the acute-phase response to strenuous exercise. Verf.-Referat