Caffeine ingestion and metabolic responses of tetraplegic humans during electrical cycling

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Bibliographic Details
Title translated into German:Auswirkung von Koffein-Einnahme auf Stoffwechselreaktionen von Tetraplegikern waehrend elektrisch stimulierten Radfahrens
Author:Mohr, T.; Soeren, M. van; Graham, T.E.; Kjaer, M.
Published in:Journal of applied physiology
Published:85 (1998), 3 , S. 979-985, Lit.
Format: Publications (Database SPOLIT)
Publication Type: Journal article
Media type: Print resource
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Identification number:PU199812305965

Author's abstract

Normally, caffeine ingestion results in a wide spectrum of neural and hormonal responses, making it difficult to evaluate which are critical regulatory factors. We examined the responses to caffeine (6 mg/kg) ingestion in a group of spinal cord-injured subjects (7 tetraplegic (C5-7) and 2 paraplegic (T4) subjects) at rest and during functional electrical stimulation of their paralyzed limbs to the point of fatigue. Plasma insulin did not change, caffeine had no effect on plasma epinephrine, and there was a slight increase (P<0.05) in norepinephrine after 15 min of exercise. Nevertheless, serum free fatty acids were increased (P<0.05) after caffeine ingestion after 60 min of rest and throughout the first 15 min of exercise, but the respiratory exchange ratio was not affected. The exercise time was increased (P<0.05) by 6% or 1.26+/-0.57 min. These data suggest that caffeine had direct effects on both the adipose tissue and the active muscle. It is proposed that the ergogenic action of caffeine is occurring, at least in part, by a direct action of the drug on muscle. Verf.-Referat