Changes in bone mineral density during sexual maturation in male and female rats: correlation with serum IGF-1, IGFBP-3, osteocalcin and sex steroids
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| Deutscher übersetzter Titel: | Aenderungen der Knochenmineraldichte im Verlauf der sexuellen Reifung bei maennlichen und weiblichen Ratten: Korrelation mit IGF-1, IGF-bindendem Protein 3, Osteocalcin und den Sexualhormonen |
|---|---|
| Autor: | Fukuda, R.; Usuki, S.; Kotani, E.; Mukai, N.; Amagai, H.; Hayashi, K.; Takamatsu, K. |
| Erschienen in: | Japanese journal of physical fitness and sports medicine |
| Veröffentlicht: | 47 (1998), 1, S. 155-163, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 0039-906X, 1881-4751 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU199806302298 |
| Quelle: | BISp |
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PU199806302298 |
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Literatur |
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2009-04-27T15:32:47Z |
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2001-07-24T13:41:19Z |
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BISp |
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Zeitschriftenartikel |
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JO00000000690 |
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JOI199800010000690 |
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Japanese journal of physical fitness and sports medicine |
| hierarchy_parent_title |
Japanese journal of physical fitness and sports medicine, 1998, 1 |
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PU199806302298 |
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Changes in bone mineral density during sexual maturation in male and female rats: correlation with serum IGF-1, IGFBP-3, osteocalcin and sex steroids |
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0155 |
| recordtype |
bisparticle |
| publishDate |
1998 |
| publishDate_facet |
1998 |
| language |
eng |
| title |
Changes in bone mineral density during sexual maturation in male and female rats: correlation with serum IGF-1, IGFBP-3, osteocalcin and sex steroids |
| spellingShingle |
Changes in bone mineral density during sexual maturation in male and female rats: correlation with serum IGF-1, IGFBP-3, osteocalcin and sex steroids Entwicklung, körperliche Frau Globulin, hormonbindendes Knochen Knochendichte Mann Osteocalcin Reifung Sexualhormon Sportmedizin Testosteron Tierversuch Wachstumsfaktor Östradiol |
| title_sort |
changes in bone mineral density during sexual maturation in male and female rats correlation with serum igf1 igfbp3 osteocalcin and sex steroids |
| title_short |
Changes in bone mineral density during sexual maturation in male and female rats: correlation with serum IGF-1, IGFBP-3, osteocalcin and sex steroids |
| title_alt |
Aenderungen der Knochenmineraldichte im Verlauf der sexuellen Reifung bei maennlichen und weiblichen Ratten: Korrelation mit IGF-1, IGF-bindendem Protein 3, Osteocalcin und den Sexualhormonen |
| title_alt_lang |
deu |
| media_type |
Gedruckte Ressource |
| city |
Tokio |
| abstract |
Bone (tibia, femur, and lumbar spine) and blood samples were obtained from 100 (50 males and 50 females) Wistar-Imamichi rats in groups aged 3, 5, 7, 9, 12, 15 and 20 weeks old to investigate the changes in bone mass during puberty in relation to insulin-like growth factor 1 (IGF-I), IGF binding protein (IGFBP)-3, osteocalcin (OC) and sex steroids in normal rats. Sharp increases in BMD (bone mineral density) in the tibia, femur and lumbar appeared earlier in female than in male rats, and the BMD in females tended to be higher than in males between 5 and 9 weeks old. After 9 weeks old, BMD in males was higher than that in females, as BMD in males continued to increase whereas that in females tended to remain in a steady state after this stage. This sex-related difference in changes in BMD pattern is probably related to the serum concentrations of IGF-1, IGFBP-3, testosterone, and 17 beta-estradiol with maturation. In males, marked increases in serum IGF-1 and IGFBP-3 concentrations appeared earlier than that in serum testosterone level. IGF-1 and testosterone peaked at 9 weeks of age, and thereafter remained in a steady state, whereas IGFBP-3 reached a peak at 7 weeks of age, and then declined gradually. In females, the changes in patterns of serum 17 beta-estradiol, IGF-1, and IGFBP-3 levels were very similar. The levels increased gradually from 3-5 weeks old, peaked at 9 weeks, and then decreased slowly thereafter. In contrast, serum OC concentrations remained relatively high from 3 to 9 and from 3 to 7 weeks old in males and females, respectively, although OC in both sexes declined gradually with aging. These observations suggest that BMD development occurs earlier in female than in male rats. This sex-related difference in changes in the BMD pattern may result from the earlier onset of puberty in females, and from the sex-specific differences in concentrations of IGF-1, IGFBP-3 and sex steroids with maturation. Verf.-Referat |
| abstract_lang |
eng |
| abstract_type |
author |
| author2 |
Fukuda, R. Usuki, S. Kotani, E. Mukai, N. Amagai, H. Hayashi, K. Takamatsu, K. |
| author_facet |
Fukuda, R. Usuki, S. Kotani, E. Mukai, N. Amagai, H. Hayashi, K. Takamatsu, K. |
| author2-role |
Autor Autor Autor Autor Autor Autor Autor |
| author2-authorityid |
|
| author_author_facet |
Fukuda, R. Usuki, S. Kotani, E. Mukai, N. Amagai, H. Hayashi, K. Takamatsu, K. |
| author2-synonym |
|
| author2_hierarchy_facet |
0/Autor/ 1/Autor/Fukuda, R./ 0/Autor/ 1/Autor/Usuki, S./ 0/Autor/ 1/Autor/Kotani, E./ 0/Autor/ 1/Autor/Mukai, N./ 0/Autor/ 1/Autor/Amagai, H./ 0/Autor/ 1/Autor/Hayashi, K./ 0/Autor/ 1/Autor/Takamatsu, K./ |
| issn |
0039-906X 1881-4751 |
| spelling |
0039-906X 1881-4751 TAKAA 600775-2 Entwicklung, körperliche Frau Globulin, hormonbindendes Knochen Knochendichte Mann Osteocalcin Reifung Sexualhormon Sportmedizin Testosteron Tierversuch Wachstumsfaktor Östradiol animal experiment bone bone density estradiol growth factor hormone-binding globulin man maturation osteocalcin physical development sexual hormone sports medicine testosterone woman Maturität Pubeszenz Reife Männerklasse Diskriminierung, geschlechtliche Frauengymnastik Frauentraining Hausfrau Knochenzyste Spongiosaplastik Knochenspan Knochenradiographie Osteoplastik Maus Ratte Tierexperiment Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf Changes in bone mineral density during sexual maturation in male and female rats: correlation with serum IGF-1, IGFBP-3, osteocalcin and sex steroids PU199806302298 199806302298 |
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TAKAA |
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600775-2 |
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0/Japan/ |
| topic |
Entwicklung, körperliche Frau Globulin, hormonbindendes Knochen Knochendichte Mann Osteocalcin Reifung Sexualhormon Sportmedizin Testosteron Tierversuch Wachstumsfaktor Östradiol |
| topic_facet |
Entwicklung, körperliche Frau Globulin, hormonbindendes Knochen Knochendichte Mann Osteocalcin Reifung Sexualhormon Sportmedizin Testosteron Tierversuch Wachstumsfaktor Östradiol |
| topic_en |
animal experiment bone bone density estradiol growth factor hormone-binding globulin man maturation osteocalcin physical development sexual hormone sports medicine testosterone woman |
| topic_en_facet |
animal experiment bone bone density estradiol growth factor hormone-binding globulin man maturation osteocalcin physical development sexual hormone sports medicine testosterone woman |
| synonym |
Maturität Pubeszenz Reife Männerklasse Diskriminierung, geschlechtliche Frauengymnastik Frauentraining Hausfrau Knochenzyste Spongiosaplastik Knochenspan Knochenradiographie Osteoplastik Maus Ratte Tierexperiment Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf |
| journal_facet |
Japanese journal of physical fitness and sports medicine |
| container_title |
Japanese journal of physical fitness and sports medicine |
| container_volume |
47 |
| container_issue |
1 |
| container_start_page |
S. 155-163 |
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1 |
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BISp |
| journal_fac |
JO00000000690 |
| journal_year |
1998 |
| journal_issue |
1 |
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1791516840024866816 |
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13,55836 |