Abstract des Autors

Several steroid test samples have been invalidated since 1994 by the IOC laboratories in Montreal, Lausanne, Huddinge and Tokyo because of the presence of the unknown undeclared agent. The identification of this bromine containing compounds was made by Ayotte in the middle of 1996 in cooperation with International Amateur Athletic Federation. The compound, bromantane, is a adamantane derivative that has the parabromaniline side chain, and was developed in Russia as immuno-stimulator. In Russia, it has been used among militaries and sportsmen as the unauthorized medicine. Later in centennial Olympic in Atlanta, nine bromantane cases were found but the findings were not resulted in disqualification because of the legal problem. This paper refers to a positive case of bromantane. Our results demonstrated that overdose of bromantane could manipulate the urinary steroid profiles. lt is not just an interfering and a co-elution but also the manipulation of the chromatographic behavior of the steroids. The simple extraction procedure to eliminate the influence of bromantane on the steroid profiles is given. Verf.-Referat