Metabolism of benzphetamine and clobenzorex in human urine
| Deutscher übersetzter Titel: | Metaboliten von Benzphetamin und Clobenzorex im menschlichen Urin |
|---|---|
| Autor: | Tsoutsoulova-Draganova, A.; Halatcheva, N.; Karova, D. |
| Herausgeber: | Schänzer, Wilhelm; Geyer, Hans; Gotzmann, Andrea; Marek-Engelke, U. |
| Erschienen in: | Recent advances in doping analysis (5) : Proceedings of the Manfred Donike Workshop ; 15th Cologne Workshop on Dope Analysis ; 23rd to 28th February 1997 |
| Veröffentlicht: | Köln: Sport u. Buch Strauß (Verlag), 1998, S. 231-248, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Gedruckte Ressource |
| Sprache: | Englisch |
| ISBN: | 3890010164 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU199805301856 |
| Quelle: | BISp |
Abstract
The metabolism of the stimulants Benzphetamine and Clobenzorex in the human urine after a single oral dose are investigated. Several new hydroxymetabolites of Benzphetamine and Clobenzorex as well as the well-known metabolites - amphetamine, methamphetamine and desmethylbenzphetamine - are found and identified in the collected urines up to 48th hour after administration. Conjugated urinary metabolites are detected after hydrolysis. Their structures are identified by gas chromatography/mass spectrometry using the different derivatization procedures - methylation, silyllation, selective derivatization, cyclization with methaneboronic acid. The fragmentation of some type of different derivatives is discussed and the probable metabolism scheme of Benzphetamine and Clobenzorex is proposed. Verf.-Referat