Epiandrosterone glucuronide as a sign to indicate natural hormone doping

Gespeichert in:
Bibliographische Detailangaben
Deutscher übersetzter Titel:Epiandrosteronglukuronid als Hinweis auf Doping mit koerpereigenen Substanzen
Autor:Ueki, M.; Okano, M.; Ikekita, A.; Hiruma, T.; Sato, M.
Herausgeber:Schänzer, Wilhelm; Geyer, Hans; Gotzmann, Andrea; Marek-Engelke, U.
Erschienen in:Recent advances in doping analysis (5) : Proceedings of the Manfred Donike Workshop ; 15th Cologne Workshop on Dope Analysis ; 23rd to 28th February 1997
Veröffentlicht:Köln: Sport u. Buch Strauß (Verlag), 1998, 1998. S. 71-82, Lit., Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Sammelwerksbeitrag
Medienart: Gedruckte Ressource
Sprache:Englisch
ISBN:3890010164
Schlagworte:
Online Zugang:
Erfassungsnummer:PU199805301829
Quelle:BISp

Abstract des Autors

One difficulty of dope analysis stems from the origin of the dope agents. As the detection of synthetic anabolic steroid became relatively easy and since there was no procedure available that couId differentiate certain exogenous natural hormones, several physiological steroids, its esters and the precursors became a popular substitute of synthetic anabolic agents. For steroid abusers, the main purpose of the use of the free or the various ester form of T and DHT is not just a performance enhancement because the products were proven to be less anabolic and more androgenic than synthetic anabolic steroids. This paper refers to the re-investigation of the metabolism of T and DHT by means of stable isotope methodology. 19,19,19-trideuteromethylated tracers were applied to adult male volunteers and the urinary steroid profiles were measured after fractionation of the conjugates. The formation of 3 beta-hydroxy metabolites, e.g. 5alpha-androstane-3beta, 17beta-diol and epiandrosterone in the glucuronide fraction appeared to be the important sign of the exogenous application of T and DHT. Major part of these steroids were usually sulfo conjugated, and no significant amount of 3 beta-hydroxy steroid glucuronides present in the urine of hCG stimulation test samples. The difference of the metabolism between the exogenous steroids and the endogenously secreted steroids became clear by our studies. Verf.-Referat