Proteines porteuses des somatomedines et force isometrique de prehension dans un groupe de gymnastes adolescents soumis a un entrainement intensif

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Deutscher übersetzter Titel:Wachstumsfaktorenbindende Proteine und isometrische Greifkraft bei intensiv trainierenden jugendlichen Kunstturner(inne)n
Autor:Brun, J.F.; Blachon, C.; Micallef, J.P.; Fédou, C.; Charpiat, A.; Bouix, O.; Orsetti, A.
Erschienen in:Science & sports
Veröffentlicht:11 (1996), 3, S. 157-165, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Gedruckte Ressource Elektronische Ressource (online)
Sprache:Französisch
ISSN:0765-1597, 1778-4131
DOI:10.1016/0765-1597(96)84028-7
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Erfassungsnummer:PU199707205899
Quelle:BISp

Abstract des Autors

Growth hormone and insulin-like growth factor 1 (IGF1) are a major anabolic system in the body. They have been reported to be correlated to fitness. More recently, insulin-like growth factor-binding proteins (IGFBPs) have been shown to modulate the biological action of IGF1. In this study we aimed at evaluating the relationships among IGF1, IGFBPs and strength measurements in adolescent gymnasts submitted to a hard training program. In 37 gymnasts (13 boys, 24 girls) aged from 10 to 15 years undergoing 18 to 20 hours of training each week in a sports-study school section, IGF1, IGFBP1, and IGFBP3 were studied in comparison with measurements performed with home made ergometers designed for handgrip and adductor isometric strength measurements. Nutritional assessment showed that children were eating 2.670+/-380 kcal/day, including 16% (+2) proteins, 39% (+3) lipids and 45% (+l) carbohydrates. Serum IGF1 values (girls: 31.02+/-2.04 nMol/L: boys: 26.34+/-2.27 nMol/L) were within the control range, as were also IGFBP3 (girls: 4.39+/-0.23 mg/L: boys: 4.68+/-0.33 mg/L). Although the normal range for IGFBP1 is less well defined, IGFBP1 values (girls: 23.89+/-6.28 ng/mL: boys: 65.6+/-22.52 ng/mL) seemed to be lowered. In the whole sample, a positive correlation was found between isometric handgrip strength and both IGF1 (r=0.345, P<0.05) and IGFBP3 (r=0.489, P<0.01). This correlation is not explained by age, which is not a determinant of handgrip strength in this sample. IGFBP1 is negatively correlated to IGFBP3 (r=-0.431, P<0.01). IGFBP1 decreases during puberty while IGFBP3 and IGF1 slightly increase. In the 13 boys, isometric handgrip strength was correlated to IGF1 and IGFBP3. A partial correlation analysis selects IGFBP3 as a better statistical determinant (r=0.468) than IGF1 (r=0.13). IGFBP1 is negatively correlated to IGF1 (r=-0.553, P<0.05) and IGFBP3 (r=-0.765, P<0.01). Age and duration of previous practice of gymnastics were not correlated to these serum proteins and are not likely to explain these correlations. In the sample of 24 girls, these correlations are not significant. Thus, isometric strength (ie, a parameter involved in performance in gymnasts) is correlated with two markers of GH status: IGF1 and IGFBP3. This could be explained by the anabolic action of the GH/IGF1 axis on muscle. Low IGFBP1 may point out that those gymnasts are not undernourished. The correlation between IGFBP3 and strength may suggest an interest for this marker of GH action in the assessment of fitness in sports medicine. Verf.-Referat