Abstract des Autors

The effect of 12 wk of submaximal training on hemostatic variables was studied in 20 young sedentary men (Tr) and 19 nontraining matched controls (Con). After training, a more pronounced increase in factor VIII coagulant activity, reflected in a decrease in activated partial thromboplastin time during maximal exercise, was seen. Both basal plasminogen activator inhibitor 1 antigen (PAL-1 Ag) and activity (PAI-1 Act; P<0.05), as well as basal and exercise-induced tissue-type plasminogen activator antigen (t-PA Ag; P<0.05), were decreased after training. The overall effect on fibrinolysis was reflected in an increase in the t-PA Act/t-PA Ag ratio in the Tr group. In contrast, during the same period (February-June), the Con group demonstrated an increase in basal PAI-1 Ag and PAI-1 Act, together with an increase in basal and exercise-induced t-PA Ag. Both basal and exercise-induced t-PA Act were unchanged, but t-PA Act/t-PA AG was decreased in the Con group. We conclude that physical training promotes both coagulation and fibrinolytic potential during exercise and may reverse unfavorable seasonal effects on fibrinolysis. Verf.-Referat