Abstract

One primary goal of the present undertaking was to provide a basic review of the extracellular and intracellular components that constitute the regulatory systems of the living cell. Included is a description of the transduction between the two types of components, including the role of Ca++ and the role of phopsphorylation in the regulation of cardiac and skeletal muscle. The second goal was to explore the experimental evidence that deals with the effects of both acute and chronic exercise on the metabolism of cAMP and protein kinase in cardiac and skeletal muscle. Part I is an overview of phopsphorylation with the chapters: 1. Phosphorylation of cell membrane calcium channel proteins; 2. cAMP-dependent phopsphorylation of sarcoplasmic reticulum proteins; 3. Myofibrillar protein phosphorylation (troponin). Part II describes the effects of exercise on cAMP and cAMP-dependent protein kinase: 1. Exercise, cAMP, and cAMP-dependent protein kinase in cardiac muscle; 2. Effects of prolonged exercise and training on skeletal muscle cAMP and cAMP-dependent protein kinase. Part III summarizes this information: Present understanding of the cAMP system in the adaptations of muscle to exercise. aus dem Vorwort