Abstract des Autors

The effect of 2.5 h of treadmill running at 75.6+/-0.9% VO2max on circulating leucocyte and lymphocyte subpopulations, epinephrine and cortisol concentrations, and the Con A-induced lymphocyte proliferative response was investigated in 22 experienced marathon runners. Blood samples were taken 15 min before (07.15 h) and immediatley after exercise (10:00 h), with three more samples taken during 6 h of recovery (11.30, 13.00, 16.00 h). Ten sedentary controls sat in the laboratory during testing and had their blood sampled at the same time points. Serum cortisol was elevated relative to controls for more than 3 h post-exercise, and correlated significantly with the 3-h post-exercise elevation of the neutrophil/lymphocyte ratio (r=0.68, p<0.001). The concanavalin A- (ConA) induced lymphocyte proliferative response was decreased relative to controls for more than 3 h post-exercise, and except for the immediate post-exercise time point, tended to parallel the decrease in T cell (CD3+) concentrations. Verf.-Referat