Einfluss von langdauernder Belastung auf die Dichte und Aktivitaet der beta-Adrenorezeptoren auf Lymphozyten
Englischer übersetzter Titel: | Effect of prolonged exercise on the density and function of beta-adrenoceptors on lymphocytes |
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Autor: | Hack, V.; Giesser, R.; Jost, J.; Weiß, M.; Welsch, B.F.; Albert, M.; Bärtsch, Peter |
Herausgeber: | Liesen, Heinz; Weiß, Michael; Baum, Matthias |
Erschienen in: | Regulations- und Repairmechanismen : 33. Deutscher Sportärztekongress Paderborn 1993 |
Veröffentlicht: | Köln: Dt. Ärzte-Verl. (Verlag), 1994, 1994. S. 561-563, Abb., Lit., Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Sammelwerksbeitrag |
Medienart: | Gedruckte Ressource |
Sprache: | Deutsch |
ISBN: | 3769103084 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199503075808 |
Quelle: | BISp |
Abstract des Autors
Short-term exercise (</= 30 min) is generally known to increase the density and function of beta2-adrenoceptors (beta-AR). However, the effect of intensive long-term exercise (>/= 1 h) on these parameters is not known. Therefore, we investigated the beta-AR density on intact mononuclear leukocytes (MNL) in triathletes (n=10) before and immediately after one hour of exhausting running, biking and swimming exercise at 105% of the IAT. The beta-AR density per MNL increased (p>/= 0.01) more than 80% after running, biking and swimming exercise, respectively, compared with pre-start values. Despite this significant increase of beta-AR density, the stimulated maximal cAMP-production increased only marginally and therefore, the beta-AR:cAMP ratio decreased significantly (p</=0.05) after exercise. The coupling, too, was markedly reduced. These results demonstrate a desensitisation at receptor or post-receptor-level after exhaustive long-term exercise. Verf.-Referat