PMN cell counts and phagocytic activity of highly trained athletes depend on training period

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Bibliographic Details
Title translated into German:Die Zahl der polymorphkernigen Leukozyten und die Phagozytose-Aktivitaet bei Hochleistungssportlern haengt von der Trainingsphase ab
Author:Hack, V.; Strobel, G.; Weiß, M.; Weicker, H.
Published in:Journal of applied physiology
Published:77 (1994), 4 , S. 1731-1735, Lit.
Format: Publications (Database SPOLIT)
Publication Type: Journal article
Media type: Print resource
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Identification number:PU199502074888

Author's abstract

We tested the hypothesis that polymorphonuclear leukocyte (PMN) cell counts and phagocytic activity determined by latex ingestion and superoxide anion production are influenced by different training periods. We investigated long-distance runners before and up to 24 h after a graded exercise test to exhaustion during moderate training (MT) and intense training (IT) and compared them with untrained (control) subjects. Cell counts and phagocytic activity at rest and after exercise did not differ significantly between MT and control. On the contrary, IT showed a significant (P </= 0.05) decrease in PMN cell count at rest (2.55 +/- 0.3 cells/nl) compared with MT (3.63 +/- 0.2 cells/nl) and control (3.41 +/- 0.8 cells/nl). Furthermore, phagocytic activity was significantly reduced (P </= 0.05) in IT at rest and after exercise compared with MT and control. A strong inverse correlation (r = -0.75; P</= 0.01) between epinephrine and superoxide anion production was found. These results provide evidence that the phagocytic activity depends on the training period and indicate impaired PMN functions during IT, which might lead to increased susceptibility to infection. Verf.-Referat