TY - JOUR AU - Lataste, X. A2 - Lataste, X. DB - BISp DP - BISp KW - Blutzufuhr KW - Durchblutung, zerebrale KW - Glukosetransport KW - Hirnstoffwechsel KW - Hirnödem KW - Hypoxie KW - Höhenphysiologie KW - Kalziumantagonist KW - Sportmedizin LA - eng TI - The blood-brain barrier in hypoxia TT - Die Blut-Gehirn-Schranke unter Hypoxie PY - 1992 N2 - The concept of blood-brain barrier has moved over the past years from a passive and relatively immutable structure to a more dynamic interface between blood and brain tissue. The transport mechanisms regulating this adaptative interface might be considered as the most sensitive elements to change such as hypoxia. Among various carrier mediated transports existing at the blood-brain barrier, glucose transport seems to play a predominant role. In severe hypoxia, progressive changes in glucose transport are occurring. These modifications associated with hypoxia can lead to deleterious events when reaching critical threshold. In addition the appearance of vasogenic edema due to changes in cerebral-blood flow, can possibly be prevented by some pharmacological interaction such as the use of selective brain calcium channel blockers. Verf.-Referat SP - S. S45-S47 SN - 0172-4622 JO - International journal of sports medicine IS - Suppl.1 VL - 13 M3 - Gedruckte Ressource ID - PU199305061921 ER -