Abstract

We studied whether or not exercise training in healthy humans elicits an increase in circulating sulfoconjugated catecholamines. Although diet was not controlled individuals reporting high physical activity demonstrated significantly elevated sulfoconjugated norepinephrine (NE-SO4) and dopamine (DA-SO4) at rest with lower free NE relative to lower fit counterparts. However, exercise training of the sedentary group for 4 months did not appreciably change the sulfoconjugated catecholamines, whereas free NE significantly declined. We conclude that if catecholamine deactivation by sulfoconjugation is augmented with exercise training, any change is dependent upon the frequency and duration of training. Furthermore, chronic exercise can induce a significant decline in circulating free NE with no change in the sulfoconjugates. Verf.-Referat