The influence of diuretics on the excretion and metabolism of doping agents - V. dimefline

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Deutscher übersetzter Titel:Einfluss von Diuretika auf Ausscheidung und Stoffwechsel von Dopingmitteln - V. Dimefline
Autor:Delbeke, F.T.; Debackere, M.
Erschienen in:Journal of pharmaceutical and biomedical analysis
Veröffentlicht:9 (1991), 1, S. 23-28, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Gedruckte Ressource
Sprache:Englisch
ISSN:0731-7085, 1873-264X
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Erfassungsnummer:PU199204053629
Quelle:BISp

Abstract

A sensitive method for the quantitative determination of the respiratory stimulant dimefline in 5 ml urine using capillary gas chromatography with nitrogen specific detection is presented. After the oral administration of a therapeutical amount of 16 mg dimefline to five subjects only 0.26 +/- 0.16 of the dose is excreted as the conjugated drug in 24 h. The maximum excretion rate occurred 3 h after dosing, the peak concentration being 154 +/- 60 ng/ml. The influence of diuretics taken 2 h after the administration of dimefline was studied in three subjects. From these results it appeared that the use of acetazolamide and hydrochlorthiazide in order to circumvent a positive dimefline doping case is questionable. Due to the potent diuretic effect of furosemide, the intake of this diuretic could result in a suppression of the dimefline concentration below the detection limit of 10 ng/ml. Verf.-Referat