Plasma adrenaline and noradrenaline during orthostasis in man: the importance of arterial sampling

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Deutscher übersetzter Titel:Plasma-Adrenalin und -Noradrenalin beim Menschen waehrend Orthostase: die Wichtigkeit des Messens der arteriellen Konzentrationen
Autor:Kjeldsen, Sverre Erik; Westheim, Arne; Aakesson, Ingvar; Eide, Ivar; Leren, Paul
Erschienen in:The Scandinavian journal of clinical & laboratory investigation
Veröffentlicht:46 (1986), 5, S. 397-401, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Gedruckte Ressource
Sprache:Englisch
ISSN:0036-5513, 1502-7686
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Erfassungsnummer:PU198705029723
Quelle:BISp

Abstract

Plasma adrenaline and noradrenaline were measured in arterial blood and in forearm venous blood during supine rest and after 30 min standing in normotensive, healthy 50-yr-old men (n=16). After 30 min standing, venous noradrenaline had increased from 1.61 +/- 0.11 to 4.22 +/- 0.30 nmol/l and arterial from 1.43 +/- 0.06 to 2.93 +/- 0.15 nmol/l. Orthostasis induced a seven-fold increment in the forearm arterial-venous difference of noradrenaline from -0.18 +/- 0.08 to -1.29 +/- 0.25 nmol/l (<0.001). Orthostasis more than doubled the forearm arterial-venous difference of adrenaline from 0.15 +/- 0.03 to 0.31 +/- 0.05 nmol/l (p<0.001) since arterial adrenaline increased from 0.31 +/- 0.03 to 0.53 +/- 0.05 nmol/l and venous from 0.16 +/- 0.02 to 0.22 +/- 0.02 nmol/l. Arterial adrenaline correlated significantly with venous in the supine (r=0.64, p<0.01) but not in the standing position (r=0.34, NS). The results indicate that arterial concentrations of adrenaline are a much better indicator of sympatho-adrenal activity during orthostasis than peripheral venous concentrations. For noradrenaline, measurements of arterial concentrations during the orthostatic manoeuvre seem to provide information about the total noradrenergic sympathetic reactivity, while the corresponding measurements in peripheral venous blood represent the forearm locally. Verf.-Referat