Abstract

Eight athletes (T), studied the third morning after the last exercise session, and seven sedentary males (C) had insulin infused until plasma glucose, at an insulin level of 1,600 pmol/l, was 1.9 mmol/l. Glucose turnover was determined by primed constant rate infusion of 3-(3H)glucose. Basal C-peptide and glucagon were lower and epinephrine higher in T than in C subjects. During and after insulin infusion production, disappearance and clearance of glucose changed identically in T and C subjects. However, in spite of identical plasma glucose concentrations, epinephrine, growth hormone, and pancreatic polypeptide reached higher levels and glucagon lower levels in T than in C subjects. Blood pressures changed earlier in athletes during insulin infusion, and early recovery of heart rate, free fatty acid, and glycerol was faster. Responses of norepinephrine, cortisol, C-peptide, and lactate were similar in the two groups. Training radically changes hormonal responses but not glucose kinetics in insulin hypoglycemia. Verf.-Referat