Abstract

A total of 182 male Sprague-Dawley rats weighting 250-300 g were fed either a control (n = 60) or low-potassium (n = 122) diet for 32 days. The diets contained either 125 or 8 meq potassium/kg, respectively. Rats fed the low-K+ diet gained weight at only one-third the rate of controls (1.7 vs. 5.2 g/day), and their skeletal muscle and plasma potassium levels were reduced by 28 and 47, respectively. When run to exhaustion at either 15 or 20 degrees C, low K+-fed rats accomplished less than one-half of the work done by the controls (26 vs. 53 kg/m) but exhibited a markedly greater rate of heat gain per kilogram-meter of work than controls (0.12 vs. 0.05 degree C). At an ambient temperature of 20 degrees C, the rats of the low-K+ group, despite large differences in body weight (-25), run time (-37), and work done (-49), had identical postrun core temperatures and twice (33 vs. 17) the mortality rate of the controls. Postexercise increases in circulating potassium of heat-injured rats raised the plasma levels of low K+-fed rats to normal (5.9 +/- 2.2 meq/l). These results appear to characterize the existence of an insidious and, therefore, undocumented form of fatal exertion-induced heat illness. Verf.-Referat