Role of physical effort in the etiology of rat heatstroke injury and mortality
| Deutscher übersetzter Titel: | Die Rolle koerperlicher Anstrengung bei der Aetiologie der Verletzung und Sterblichkeit durch Hitzschlag bei der Ratte |
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| Autor: | Hubbard, R.W.; Matthew, W.T.; Criss, E.E.L.; Kelly, C.; Sils, I.; Mager, M.; Bowers, W.D.; Wolfe, D. |
| Erschienen in: | Journal of applied physiology |
| Veröffentlicht: | 45 (1978), 3, S. 463-468, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 8750-7587, 0021-8987, 0161-7567, 1522-1601 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU198001010166 |
| Quelle: | BISp |
Abstract
A total of 171 untrained, unacclimatized, and unanesthetized rats were used to evaluate the effects of sedentary and work-induced hyperthermia on the incidence of mortality and cellular injury, 24 h postexposure. Cellular injurywas defined as serum transaminase activity (SGPT and SGOT) exeeding 1,000 IU/1(heatstroke levels). Both the percent mortality and the percentage of 24-h survivors with transaminase levels above 1,000 IU/1 were plotted against maximum core temperatures. Exertion-induced hyperthermia produced a significantly higher incidence of cellular injury and heatstroke death at lower core temperatures than hyperthermia alone. With hyperthermia only, the SGPT and SGOT dose-response curves were identical. When work was combined with hyperthermia,there was a greater incidence of elevated SGOT at lower core temperatures. These curves bore a striking resemblance to curves reflecting heat- and/or work-induced mortality in humans. The results suggest a direct role of physical effort in causing heatstroke injury and mortality. Verf.-Referat