Abstract

This study was designed to determine if strenuous physical training might normalize initially atypical response to the oral fat tolerance test. Twenty-fourmiddle-aged men with known elevated blood lipid levels were screened for abnormal response to the oral fat tolerance test. Blood samples were taken from theantecubital vein early in the morning following a 12 hour fast, and at 3, 5, and 7 hours after ingestion of a high fat meal. All samples were centrifuged and the serum was separated from the cells. Serum optical density was established by means of spectrophotometry. Fasting serum optical density was subtracted from those derived at later sampling to yield delta scones. Ten of themen demonstrated either exaggerated magnitude or duration of lipemia followingthe fat ingestion, or both. These ten subjects were trained by cycling, swimming or jogging for 8 weeks. The oral fat tolerance test was readministered prior to initiation of training and at each 2 weeks during training. Data wereanalyzed with analysis of variance. No statistically significant differences (P>.05) in magnitude or duration of lipemia as outcomes of fat ingestion were noted. It was concluded that abnormal oral fat tolerance is an inborn error of metabolism not influenced by physical training. Verf.-Referat