Analysis of RBC‐microparticles in stored whole blood bags : a promising marker to detect blood doping in sports?
Gespeichert in:
| Deutscher übersetzter Titel: | Analyse von RBC-Mikropartikeln in gelagerten Vollblutbeuteln : ein vielversprechender Marker zum Nachweis von Blutdoping? |
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| Autor: | Voss, Sven Christian; Jaganjac, Morana; Al‐Thani, Amna Mohamed ; Grivel, Jean‐Charles; Raynaud, Christophe Michel; Al‐Jaber, Hind; Al‐Menhali, Afnan Saleh; Merenkov, Zeyed Ahmad; Alsayrafi, Mohammed; Latiff, Aishah; Georgakopoulos, Costas G. |
| Erschienen in: | Drug testing and analysis |
| Veröffentlicht: | 9 (2017), 11/12 (35th Cologne workshop: Advances in sports drug testing), S. 1794-1798, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 1942-7603, 1942-7611 |
| DOI: | 10.1002/dta.2212 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201803002069 |
| Quelle: | BISp |
Abstract des Autors
Blood doping in sports is prohibited by the World Anti‐Doping Agency (WADA). To find a possible biomarker for the detection of blood doping, we investigated the changes in blood stored in CPDA‐1 blood bags of eight healthy subjects who donated one unit of blood. Aliquots were taken on days 0, 14, and 35. Platelet‐free plasma was prepared and stored at −80°C until analysis on a flow cytometer dedicated for the analysis of microparticles (MPs). Changes in the number of red blood cell (RBC) ‐MPs were highly significant (p < 0.0001) with a mean of 219 (10^3/μL) on day 0 changing to 23 120 (10^3/μL) on day 14 and 29 310 (10^3/μL) on day 35. We conclude that RBC‐MPs seem to be a promising biomarker for doping control but confirmation by a transfusion study is necessary