Isolation and characterization of a newly identified impurity in methamphetamine synthesized via reductive amination of 1-phenyl-2-propanone (P2P) made from phenylacetic acid/lead (II) acetate
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| Deutscher übersetzter Titel: | Isolierung und Charakterisierung einer neu identifizierten Verunreinigung von Methamphetamin, hergestellt durch reduktive Aminierung von 1-Phenyl-2-Propanon (P2P) aus Phenylessigsäure/Blei(II) Acetat |
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| Autor: | Toske, Steven G.; McConnell, Jennifer B.; Brown, Jaclyn L.; Tuten, Jennifer M.; Miller, Erin E.; Phillips, Monica Z.; Vazquez, Etienne R.; Lurie, Ira S.; Hays , Patrick A.; Guest, Elizabeth M. |
| Erschienen in: | Drug testing and analysis |
| Veröffentlicht: | 9 (2017), 3/4 (Addressing the challenges in forensic drug chemistry), S. 453-461, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 1942-7603, 1942-7611 |
| DOI: | 10.1002/dta.1814 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201705003840 |
| Quelle: | BISp |
Abstract des Autors
A trace processing impurity found in certain methamphetamine exhibits was isolated and identified as trans-N-methyl-4-methyl-5-phenyl-4-penten-2-amine hydrochloride (1). It was determined that this impurity was produced via reductive amination of trans-4-methyl-5-phenyl-4-penten-2-one (4), which was one of a cluster of related ketones generated during the synthesis of 1-phenyl-2-propanone (P2P) from phenylacetic acid and lead (II) acetate. This two-step sequence resulted in methamphetamine containing elevated levels of 1. In contrast, methamphetamine produced from P2P made by other methods produced insignificant (ultra-trace or undetectable) amounts of 1. These results confirm that 1 is a synthetic marker compound for the phenylacetic acid and lead (II) acetate method. Analytical data for 1 and 4, and a postulated mechanism for the production of 4, are presented.