Prolonged androgenic anabolic steroid (AAS) induced QT interval shortening : a suitable screening tool?
Deutscher übersetzter Titel: | Andauernde Gabe von androgenen anabolen Steroiden (AAS) induziert QT-Intervall Verkürzung : ein geeignetes Screening-Tool ? |
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Autor: | Sculthorpe, Nicholas; Taylor, Lee |
Erschienen in: | Drug testing and analysis |
Veröffentlicht: | 8 (2016), 1/2, S. 120-122, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 1942-7603, 1942-7611 |
DOI: | 10.1002/dta.1826 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU201608005771 |
Quelle: | BISp |
Abstract des Autors
Androgenic anabolic steroid (AAS) abuse is associated with changes in cardiac electrophysiology. Recently heart rate corrected QT interval (QTc) has been suggested as a method of screening for AAS use in athletes despite conflicting reports. This study aimed to further investigate the effect of AAS on QTc in a cohort of long-term AAS users in whom the affects may be more pronounced. Using a cross-sectional cohort design with AAS using resistance trained athletes (AS n = 15) and a group of non-AAS using resistance trained, age matched controls (C n = 15). AS had a long history of AAS use (18 ± 2 yrs) and AS and C both had >19 years of resistance training. Participants underwent a resting electrocardiogram (ECG), from which, the QTc interval was calculated using the Bazett formula. The main outcome measure was significant differences in mean corrected QTc between groups. A secondary outcome was to calculate a QTc that best differentiated between C and AS. Results indicated that QTc was shorter in AS than in C (382.0 ± 21.01 ms versus 409 ± 18.77 ms for AS and C respectively p < 0.001). Chi squared analyses revealed a greater incidence of QTc < 380 ms in AS versus C p < 0.01, specificity 93% sensitivity 60%). In conclusion these results supports previous findings that AAS use causes a reduction in QTc, however, the specificity and sensitivity in our sample is lower than reported previously and precludes use as a screening tool.