Within-subject haemoglobin variation in elite athletes : a longitudinal investigation of 13887 haemoglobin concentration readings

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Deutscher übersetzter Titel:Intraindividuelle Hämoglobin-Variationen bei Hochleistungssportlern : eine Längsschnittuntersuchung von 13887 Messungen der Hämoglobinkonzentration
Autor:Lobigs, Louisa M.; Knight, Emma J.; Schumacher, Yorck Olaf; Gore, Christopher J.
Erschienen in:Drug testing and analysis
Veröffentlicht:8 (2016), 1/2, S. 228-234, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Elektronische Ressource (online) Gedruckte Ressource
Sprache:Englisch
ISSN:1942-7603, 1942-7611
DOI:10.1002/dta.1809
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Erfassungsnummer:PU201607005325
Quelle:BISp

Abstract des Autors

The Athlete Biological Passport (ABP) estimates individualized reference ranges for key blood markers, such as haemoglobin concentration ([Hb]), using predetermined population mean, between- and within-subject variances. Here, we aim to reassess previously published estimates for within-subject [Hb] variance and determine whether sex-, analyzer-, sport-, or season-specific values are required. Our reference population contains 7723 male (mean ± SD, 22.3 ± 4.6 years of age) and 6164 female (21.6 ± 4.3) athlete observations from 49 sports. [Hb] was calculated using one of three cytometers; Bayer-H3 (1997–1999, n = 4554), ADVIA-120 (1999–2010, n = 8636) and Sysmex XT-2000i (2010–2012, n = 697). The final model was a linear mixed model for [Hb] with analyzer (H3, ADVIA, Sysmex), sex (male, female), sport (power-endurance, endurance, skill, team, disabled and non-athletes), season (summer, winter), and the interaction between sex and sport as fixed effects and athlete as a random effect. The model included an exponential correlation structure to allow for within-subject autocorrelation, and allowed different within-subject variances for each sport. Within-subject [Hb] variance (g2/L2) was significantly less for power endurance (35.09, 95% CI 33.50 to 36.76), disabled (25.82, 95% CI 21.71 to 35.28) and non-athletes (34.30, 95% CI 28.53 to 35.87) than for endurance (40.35, 95% CI 39.62 to 47.22) and team sports (38.70, 95% CI 37.68 to 39.76) athletes. No new evidence was found to justify adjusting the current within-subject [Hb] variance estimate.