Alterations in resting-state brain networks in concussed adolescent athletes
Deutscher übersetzter Titel: | Veränderungen im Ruhezustands-Hirnnetzwerk bei jugendlichen Sportlern mit Gehirnerschütterung |
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Autor: | Borich, Michael; Babul, Aliya-Nur; Yuan, Po Hsiang; Boyd, Lara A.; Virji-Babul, Naznin |
Erschienen in: | Journal of neurotrauma |
Veröffentlicht: | 32 (2015), 4, S. 265-271, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0897-7151, 1557-9042 |
DOI: | 10.1089/neu.2013.3269 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU201606003326 |
Quelle: | BISp |
Abstract des Autors
Sports-related concussion in adolescents is a major public health issue; however, little is known about the underlying changes in functional brain connectivity. We evaluated connectivity of resting-state brain networks to determine whether alterations in specific networks distinguish adolescents with sports-related concussion from a group of healthy, active control adolescents. Twelve adolescents with a clinical diagnosis of subacute concussion and ten healthy adolescents matched for age, gender, and physical activity completed functional magnetic resonance imaging (fMRI) scanning. Functional connectivity of resting-state brain networks was evaluated in both groups using probabilistic independent component analysis (ICA). Altered functional connectivity was found within three resting-state networks in adolescents with concussion. Specifically, we noted: a) alterations within the default mode network; b) increased connectivity in the right frontal pole in the executive function network; and c) increased connectivity in the left frontal operculum cortex associated with the ventral attention network. This preliminary report shows that whole-brain functional connectivity is altered in networks related to cognition and attention in adolescents in the subacute phase following sports-related concussion. This first report in adolescents should be used to inform future studies in larger cohorts of adolescents with sports-related concussion. Increased knowledge of these changes may lead to improvements in clinical management and help to develop rehabilitation programs.