Effect of ultra-endurance exercise on left ventricular performance and plasma cytokines in healthy trained men
Deutscher übersetzter Titel: | Effekte von Ultraausdauerbelastungen auf die Leistung des linken Ventrikels und Plasmazytokine bei gesunden trainierten Männern |
---|---|
Autor: | Krzeminski, Krzysztof; Buraczewska, Monika; Miskiewicz, Zbigniew; Dąbrowski, Jan; Steczkowska, Marta; Kozacz, Agnieszka; Ziemba, Andrzej |
Erschienen in: | Biology of sport |
Veröffentlicht: | 33 (2016), 1, S. 63-69, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0860-021X, 2083-1862 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU201603001470 |
Quelle: | BISp |
Abstract des Autors
The purpose of this study was to investigate the effect of ultra-endurance exercise on left ventricular (LV) performance and plasma concentration of interleukin (IL)-6, IL-10, IL-18 and tumour necrosis factor alpha (TNF-α) as well as to examine the relationships between exercise-induced changes in plasma cytokines and those in echocardiographic indices of LV function in ultra-marathon runners. Nine healthy trained men (mean age 30+/-1.0 years) participated in a 100-km ultra-marathon. Heart rate, blood pressure, ejection fraction (EF), fractional shortening (FS), ratio of early (E) to late (A) mitral inflow peak velocities (E/A), ratio of early (E’) to late (A’) diastolic mitral annulus peak velocities (E’/A’) and E-wave deceleration time (DT) were obtained by echocardiography before, immediately after and in the 90th minute of the recovery period. Blood samples were taken before each echocardiographic evaluation. The ultra-endurance exercise caused significant increases in plasma IL-6, IL-10, IL-18 and TNF-α. Echocardiography revealed significant decreases in both E and the E/A ratio immediately after exercise, without any significant changes in EF, FS, DT or the E/E’ ratio. At the 90th minute of the recovery period, plasma TNF-α and the E/A ratio did not differ significantly from the pre-exercise values, whereas FS was significantly lower than before and immediately after exercise. The increases in plasma TNF-α correlated with changes in FS (r=0.73) and DT (r=-0.73). It is concluded that ultra-endurance exercise causes alterations in LV diastolic function. The present data suggest that TNF-α might be involved in this effect.