Exercise modalities and endothelial function : a systematic review and dose–response meta-analysis of randomized controlled trials
Deutscher übersetzter Titel: | Trainingsmodalitäten und endotheliale Funktion : eine systematische Übersicht und Dosis-Wirkungs-Metaanalyse randomisierter kontrollierter Studien |
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Autor: | Ashor, Ammar W.; Lara, Jose; Siervo, Mario; Celis-Morales, Carlos; Oggioni, Clio; Jakovljevic, Djordje G.; Mathers, John C. |
Erschienen in: | Sports medicine |
Veröffentlicht: | 45 (2015), 2, S. 279-296, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0112-1642, 1179-2035 |
DOI: | 10.1007/s40279-014-0272-9 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU201504003147 |
Quelle: | BISp |
Abstract
Background: Regular exercise is associated with enhanced nitric oxide (NO) bioavailability. Flow-mediated dilation (FMD) is used widely to assess endothelial function (EF) and NO release. Objectives: The aims of this systematic review and meta-analysis were to (i) investigate the effect of exercise modalities (aerobic, resistance or combined) on FMD; and (ii) determine which exercise and participant characteristics are most effective in improving FMD. Methods: We searched the MEDLINE, Embase, Cochrane Library, and Scopus databases for studies that met the following criteria: (i) randomized controlled trials of exercise with comparative non-exercise, usual care or sedentary groups; (ii) duration of exercise intervention ≥4 weeks; (iii) age ≥18 years; and (iv) EF measured by FMD before and after the intervention. Weighted mean differences (WMDs) with 95 % confidence interval were entered into a random effect model to estimate the pooled effect of the exercise interventions. Results: All exercise modalities enhanced EF significantly: aerobic (WMD 2.79, 95 % CI 2.12–3.45, p = 0.0001), resistance (WMD 2.52, 95 % CI 1.11–3.93, p = 0.0001) and combined (WMD 2.07, 95 % CI 0.70–3.44, p = 0.003). A dose–response relationship was observed between aerobic exercise intensity and improvement in EF. A 2 metabolic equivalents (MET) increase in absolute exercise intensity or a 10 % increase in relative exercise intensity resulted in a 1 % unit improvement in FMD. There was a positive relationship between frequency of resistance exercise sessions and improvement in EF (β 1.14, CI 0.16–2.12, p = 0.027). Conclusions: All exercise modalities improve EF significantly and there was a significant, positive relationship between aerobic exercise intensity and EF. Greater frequency, rather than intensity, of resistance exercise training enhanced EF. Verf.-Referat