Vitamin C supplementation does not influence plasma and blood mononuclear cell IL-6 and IL-10 levels after exercise

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Deutscher übersetzter Titel:Nach körperlichem Training hat die Zufuhr von Vitamin C keinen Einfluss auf das Blutplasma und die Mononuclear-cell-IL-6- und IL-10-Konzentration
Autor:Aguiló, Antoni; Monjo, Marta; Moreno, Carlos; Martinez, Pau; Martínez, Sonia; Tauler, Pedro
Erschienen in:Journal of sports sciences
Veröffentlicht:32 (2014), 17, S. 1659-1669, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Elektronische Ressource (online) Gedruckte Ressource
Sprache:Englisch
ISSN:0264-0414, 1466-447X
DOI:10.1080/02640414.2014.912759
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Erfassungsnummer:PU201501000491
Quelle:BISp

Abstract

The aim of this study was to determine whether the highest vitamin C supplementation associated with complete bioavailability influences the plasma and blood mononuclear cell IL-6 and IL-10 response to exercise. A double-blinded study of supplementation with vitamin C was performed. After 15 days of supplementation with vitamin C (500 mg • day−1, n = 16) or a placebo (n = 15), participants in the study completed a 15-km run competition. Blood samples were taken before and after competition. Oxidative stress markers, antioxidants, cortisol, IL-6 and IL-10 were determined in plasma or serum. IL-6 and IL-10 protein and mRNA levels were measured in blood mononuclear cells. Although higher plasma and blood mononuclear cell vitamin C levels were observed in the supplemented group when compared with the placebo one, the two groups showed identical exercise-induced changes in all the measured parameters. Exercise induced increased IL-6 and IL-10 levels in plasma and blood mononuclear cells. IL-6 and IL-10 mRNA levels in blood mononuclear cells increased after the competition. After recovery, IL-6 mRNA returned to basal levels and IL-10 mRNA levels remained elevated. In conclusion, exercise induced increased IL-6 and IL-10 production in blood mononuclear cells. However, vitamin C supplementation did not influence IL-6 and IL-10 response to exercise. Verf.-Referat.