Association of the MTHFR 1298A>C (rs1801131) polymorphism with speed and strength sports in Russian and Polish athletes
Deutscher übersetzter Titel: | Der Zusammenhang des MTHFR 1298A>C (rs1801131)-Polymorphismus mit kraft- und geschwindigkeitsabhängigen Sportarten bei russischen und polnischen Sportlern |
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Autor: | Zarebsk, Aleksandra; Ahmetov, Ildus I.; Sawczyn, Stanisław; Weiner, Alexandra S.; Kaczmarczyk, Mariusz; Ficek, Krzysztof; Karlowska, Agnieszka Maciejewska; Sawczuk, Marek; Leońska-Duniec, Agata; Klocek, Tomasz; Voronina, Elena N.; Boyarskikh, Uljana A.; Filipenko, Maksim L.; Cięszczyk, Paweł |
Erschienen in: | Journal of sports sciences |
Veröffentlicht: | 32 (2014), 4, S. 375-382, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0264-0414, 1466-447X |
DOI: | 10.1080/02640414.2013.825731 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU201407006434 |
Quelle: | BISp |
Abstract
It has been suggested that DNA hypomethylation because of poorer effectiveness of the 5,10-methylenetetrahydrofolate reductase (MTHFR) enzyme induces muscular growth. We hypothesised that the common, functional 1298A>C polymorphism in the MTHFR gene is associated with athletic status. To test this hypothesis, we investigated the distribution of the 1298A>C variant in Polish (n = 302) and Russian (n = 842) athletes divided into four groups: endurance, strength-endurance, sprint-strength and strength-endurance, as well as in 1540 control participants. We found different genotypes (the AC heterozygote advantage) and allele distributions among sprint-strength athletes and strength athletes than the groups of sedentary controls for each nationality. In the combined study, the allelic frequencies for the 1298C variant were 35.6% in sprint-strength athletes (OR 1.18 [1.02–1.36], P = 0.024 vs. controls) and 38.6% in strength athletes (OR 1.34 [1.10–1.64], P = 0.003 vs. controls). The results of the initial and repetition studies as well as the combined analysis suggest that the functional 1298A>C polymorphism in the MTHFR gene is associated with athletic status. The presence of the C allele seems to be beneficial in sprint-strength and strength athletes. It needs to be established whether and to what extent this effect is mediated by alteration in DNA methylation status. Verf.-Referat