ACTN3 R577X polymorphism and performance phenotypes in young Chinese male soldiers

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Deutscher übersetzter Titel:ACTN3 R577X Polymorphismus und Leistungsphänotyp bei jungen männlichen chinesischen Soldaten
Autor:Shang, Xuya; Zhang, Fu; Zhang, Li; Huang, Changlin
Erschienen in:Journal of sports sciences
Veröffentlicht:30 (2012), 2, S. 255-260, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Gedruckte Ressource
Sprache:Englisch
ISSN:0264-0414, 1466-447X
DOI:10.1080/02640414.2011.619203
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Erfassungsnummer:PU201401000074
Quelle:BISp

Abstract

Alpha-actinin-3 (ACTN3) is absent in 18% of healthy Caucasian individuals owing to homozygosity for a premature stop codon (X) at amino acid 577 (rs1815739). Previous studies have shown a strong association between ACTN3 genotype and
human athletic performance. In a study of 452 young Chinese male soldiers, we examined the distribution of ACTN3 genotypes and alleles and analysed the association between ACTN3 genotypes and athletic performance. We found that the
frequencies of the ACTN3 R577X genotype (RR 39.8%, RX 43.4%, and XX 16.8%) and R577X allele (R 61.5%, X 38.5%) in young Chinese males were not significantly different from those in Caucasians. We only observed a significant association
(P¼0.025) between ACTN3 R577X genotypes and grip strength. Participants with the XX genotype displayed significantly lower handgrip strength than individuals with the RR genotype (P¼0.021), but the difference between XX and RX means
(P¼0.258) and that between RR and RX means (P¼0.42) was not significant. We did not observe a strong association between the ACTN3 R577X genotypes and sprint phenotypes or endurance phenotypes. In conclusion, our results indicate
that the ACTN3 R577X polymorphism is most strongly associated with grip strength in young Chinese male soldiers. Verf.-Referat