Influence of a low-dose COX-2 inhibitor drug on exercise-induced inflammation, muscle damage and lipid peroxidation
Deutscher übersetzter Titel: | Einfluss eines geringdosierten COX-2-Hemmers auf die belastungsinduzierte Entzündung, Muskelschädigung und Lipidperoxidation |
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Autor: | Khoshkhahesh, Faegheh; Siahkuhain, Marefat; Fisher, Gordon; Nakhostin-Roohi, Babak |
Erschienen in: | Biology of sport |
Veröffentlicht: | 30 (2013), 1, S. 61-65, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0860-021X, 2083-1862 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU201302001306 |
Quelle: | BISp |
Abstract
The purpose of this study was to examine the effect of acute low-dose celecoxib administration on exercise-induced inflammation, muscle damage and lipid peroxidation. Twenty healthy untrained males (age: 25.5±4.5 yrs, weight: 72.7±7.9 kg, height: 177.3±7.2 cm) were randomly assigned to treatment (T) or placebo (P) groups. Blood samples were obtained before, immediately after, 3 h after and 24 h after exercise. Subjects ran for 30 min at 75% ·VO2max on a treadmill. Participants consumed 100 mg celecoxib or a placebo immediately after and 12 h after the immediately post-exercise blood sample. Total leukocytes, neutrophils, creatine kinase (CK), C-reactive protein (CRP) and malondialdehyde (MDA) were assessed at each time point. Significant increases in total leukocytes and neutrophils were observed 3 h after exercise in both groups (P<0.05). CK and CRP levels were significantly increased immediately, 3 h and 24 h after exercise in both groups (P<0.05). A significant increase in MDA was observed immediately after exercise in both groups (P<0.05); however, no significant group differences were observed for MDA or CK. These findings suggest that inhibition of cyclo-oxygenase activity with low-dose celecoxib does not affect exercise-induced inflammation, muscle damage, or lipid peroxidation. Verf.-Referat