Voltammetric determination of promethazine hydrochloride at a multi-wall carbon nanotube modified glassy carbon electrode
Deutscher übersetzter Titel: | Voltammetrische Bestimmung von Promethazin-Hydrochlorid durch eine modifizierte Glaskohlenstoff-Elektrode in einer mehrwandigen Kohlenstoff-Nanoröhre |
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Autor: | Xi, Xia; Ming, Liang; Liu, Jie |
Erschienen in: | Drug testing and analysis |
Veröffentlicht: | 3 (2011), 3, S. 182-186, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 1942-7603, 1942-7611 |
DOI: | 10.1002/dta.205 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU201110008968 |
Quelle: | BISp |
Abstract
A simple and sensitive method is described for voltammetric determination of promethazine hydrochloride (PMZ), a widely used phenothiazine drug, based on its electrochemical oxidation at a multi-wall carbon nanotube (MWCNT) modified glassy carbon electrode (GCE). Compared with bare GCE, the MWCNT-modified GCE exhibited excellent enhancement effect on the electrochemical oxidation of PMZ. PMZ yielded two anodic peaks at about 0.61 V and 0.78 V, and the peak at 0.61 V was applied to the determination. Under optimized conditions, the anodic peak current was linear to the concentration of PMZ in the range from 5.0 × 10−8 to 4.0 × 10−4 M with the detection limit of 1.0 × 10−8 M. The relative standard deviation (RSD) was 2.28% for 8.0 × 10−6 M PMZ (n = 10). To further validate its possible application, the proposed method was successfully used for the quantification of PMZ in pharmaceutical formulations and biological fluids with satisfactory results. Verf.-Referat