The effect of unloading and reloading on the extracellular matrix in skeletal muscle : changes in muscle strength and motor activity
Deutscher übersetzter Titel: | Die Auswirkungen des Entlastens und Belastens auf die extrazelluläre Matrix der Skelettmuskulatur : Veränderungen in der Muskelkraft und der motorischen Aktivität |
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Autor: | Riso, Eva-Maria; Ahtikoski, A.M.; Takala, T.E.S.; Seene, T. |
Erschienen in: | Biology of sport |
Veröffentlicht: | 27 (2010), 2, S. 89-94, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0860-021X, 2083-1862 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU201101000122 |
Quelle: | BISp |
Abstract
During three weeks of hindlimb suspension muscle mass decreased 36 % (p < 0.05) in Soleus (Sol) muscle, 17 % (p < 0.05) in Gastrocnemius (GM) and had tendences to decrease in plantaris (Pla) (15 %) and in extensor digitorum longus (EDL) (8 %) muscles. Hindlimb grip strength decreased gradually during three weeks of unloading. Specific mRNA level for type I collagen decreased during three weeks of unloading in Sol muscle by 28 % (p < 0.05) and in GM muscle by 34 % (p < 0.05). mRNA level for type III collagen decreased in Sol by 22 % (p < 0.05) and in GM by 51 % (p < 0.001). Non-fibrillar type IV collagen mRNA level decreased in both above-described muscles about 25 % (p < 0.05). Lysyl oxidase (LO) mRNA level decreased by 46 % (p < 0.05) during three weeks of unloading only in Sol muscle. Matrix metalloproteinase-2 (MMP-2) mRNA level increased during reloading period in Sol and GM muscles subsequently 28 % (p < 0.05) and 49 % (p < 0.001). During unloading the activity of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in slow-twitch (ST) and fast-twitch (FT) muscles changed in different directions: during first week of suspension, their expression decreased in Sol muscle by 31 % (p < 0.05) and increased in Pla and GM muscle subsequently by 24 % (p < 0.05) and 31 % (p < 0.001). The pretranslational level of changes in fibrillar and non-fibrillar collagen, MMP-2, LO, TIMP-1 and TIMP-2 -are shown for first time together with changes in muscle strength and motor activity during unloading and reloading. Verf.-Referat