Effects of lbuprofen and high-voltage electric stimulation on acute edema formation after blunt trauma to limbs of rats
Deutscher übersetzter Titel: | Auswirkungen von Ibuprofen und Elektrostimulation unter Hochspannung auf ein akutes Ödem nach einem stumpfen Trauma der Extremitäten von Ratten |
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Autor: | Dolan, Michael G.; Graves, Paul; Nakazawa, Chika; Delano, Teresa; Hutson, Alan; Mendel, Frank C. |
Erschienen in: | Journal of athletic training |
Veröffentlicht: | 40 (2005), 2, S. 111-115, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 1062-6050, 0160-8320, 1938-162X |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU201011008923 |
Quelle: | BISp |
Abstract
Context: Ibuprofen is widely used to manage pain and inflammation after orthopaedic trauma, but its effect on acute swelling has not been investigated. Cathodal high-voltage pulsed current (CHVPC) at 120 pulses per second and 90% of visible motor threshold is known to curb edema formation after blunt trauma to the hind limbs of rats. Objective: To examine the effects of ibuprofen, continuous CHVPC, and simultaneous ibuprofen and CHVPC on acute edema formation after blunt trauma to the hind limbs of rats. Design: Randomized, parallel-group, repeated-measures design. Setting: Laboratory animal facility.Participants: A total of 21 3-month-old Zucker Lean rats (mass = 288 ± 55 g) were studied. Intervention(s): We assessed the effects of ibuprofen, continuous CHVPC, and simultaneous ibuprofen and CHVPC on acute edema formation after blunt trauma to the hind limbs of rats. Main Outcome Measure(s): Limb volumes were measured immediately before and after trauma and every 30 minutes over the 4 hours of the experiment. Results: Volumes of treated limbs of all 3 experimental groups were smaller (P < .05) than those of untreated limbs, but no treatment was more effective than another. Conclusions: Ibuprofen, CHVPC, and simultaneous ibuprofen and CHVPC effectively curbed edema after blunt injury by roughly 50% relative to untreated but similarly injured control limbs of rats. Verf.-Referat