Influence of different types of exercise on the expression of haem oxygenase-1 in leukocytes
Deutscher übersetzter Titel: | Der Einfluss verschiedener Trainingsformen auf die Genexpression von Hämoxigenase-1 in Leukozyten |
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Autor: | Fehrenbach, E.; Nieß, Andreas Michael; Passek, F.; Sorichter, S.; Schwirtz, Ansgar; Berg, A.; Dickhuth, H.H.; Northoff, H. |
Erschienen in: | Journal of sports sciences |
Veröffentlicht: | 21 (2003), 5, S. 383-389, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0264-0414, 1466-447X |
DOI: | 10.1080/0264041031000071164 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU201001001108 |
Quelle: | BISp |
Abstract
Haem-oxygenase-1 (HO-1) is an antioxidant stress protein that is mainly induced by reactive oxygen species, inflammatory cytokines and hyperthermia. We assessed the influence of different types of exercise on HO-1 expression in leukocytes of the peripheral blood in three groups of male participants: a short exhaustive run above the lactate steady state (n = 15), eccentric exercise (n = 12) and an intensive endurance run (half-marathon, n = 12). Blood samples were taken at rest and up to 24 h after exercise. Blood lactate concentration after exercise was 9.0 +/- 2.1, 3.8 +/- 1.6 and 5.1 +/- 2.2 mmol/l (mean +/- s) for the exhaustive run, eccentric exercise and half-marathon groups, respectively (P < 0.05). Creatine kinase concentration was highest 24 h after exercise: 133 +/- 91, 231 +/- 139 and 289 +/- 221 U • l - 1 for the exhaustive run, eccentric exercise and half-marathon groups, respectively (P < 0.05). The maximal increase in leukocyte counts after exercise was 11.5 +/- 19.2, 6.2 +/- 1.4 and 14.7 +/- 2.1 × 109 / l . There was no change in HO-1 as a result of the short exhaustive run or the eccentric exercise, whereas the half-marathon had a significant stimulatory effect on HO-1-expression in lymphocytes, monocytes and granulocytes (P<0.001) using flow cytometry analyses. In conclusion, eccentric exercise alone or short-term heavy exercise are not sufficient to stimulate the antioxidative stress protein HO-1 in peripheral leukocyte. Verf.-Referat