Hemiparetic stroke alters vastus lateralis myosin heavy chain profiles between the paretic and nonparetic muscles
Gespeichert in:
| Deutscher übersetzter Titel: | Ein hemiparetischer Schlaganfall verändert die Profile der Myosin Schwerkette des vastus lateralis zwischen den gelämten und nichtgelähmten Muskeln |
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| Autor: | McKenzie, Michael J.; Yu, Shuzhen; Prior, Steven J.; Macko, Richard F.; Hafer-Macko, Charlene E. |
| Erschienen in: | Research in sports medicine |
| Veröffentlicht: | 17 (2009), 1, S. 17-27, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
| Sprache: | Englisch |
| ISSN: | 1543-8627, 1543-8635 |
| DOI: | 10.1080/15438620802678388 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU200908003923 |
| Quelle: | BISp |
Abstract des Autors
Skeletal muscle phenotype alterations following hemiparetic stroke contribute to disabilities associated with stroke. The phenotypic response following stroke is undefined. This investigation examined the myosin heavy chain (MHC) composition of the vastus lateralis (VL) of stroke survivors in paretic (P) and nonparetic (NP) muscle. Protein obtained from VL of 10 stroke survivors was isolated and purified, and MHC gel electrophoresis was performed. The MHC bands were quantified, and a paired sample two-tailed T test with significance set at p </=0.05 was performed. MHC I expression was significantly less in P versus NP VL (.93 vs. 1.00 arbitrary units [AU]). Significantly more IIx MHC was found in the P versus NP VL (1.33 vs. 1.0). No significant differences in type IIa MHC (1.07 P vs. 1.00 NP) were found. These changes in MHC composition suggest an alteration in muscle function due to stroke or the altered activity patterns of muscle following stroke. Verf.-Referat