Vibrational spectroscopic study of salbutamol hemisulphate

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Deutscher übersetzter Titel:Vibrierende spektroskopische Untersuchung von Salbutamol Hemisulfat
Autor:Ali, H.R.H.; Edwards, H.G.M.; Kendrick, J.; Scowen, I.J.
Erschienen in:Drug testing and analysis
Veröffentlicht:1 (2009), 1, S. 51-56, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Gedruckte Ressource Elektronische Ressource (online)
Sprache:Englisch
ISSN:1942-7603, 1942-7611
DOI:10.1002/dta.8
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Erfassungsnummer:PU200904002092
Quelle:BISp

Abstract

Salbutamol hemisulphate is a relatively selective 2-adrenergic agonist and is used as a bronchodilator. In this work, we present a detailed vibrational spectroscopic investigation of salbutamol hemisulphate using mid-infrared and near-infrared Fourier-transform (NIR-FT) Raman spectroscopies. These data are supported by quantum chemical calculations, which allow us to characterise the vibrational spectra of this compound reasonably. As such, this study could be viable for examining the way in which this drug interacts with its target molecules. Verf.-Referat