The long-acting phosphodiesterase inhibitor tadalafil does not influence athletes' VO2max, aerobic, and anaerobic thresholds in normoxia
Deutscher übersetzter Titel: | Der langanhaltende Phosphodiesterase Hemmstoff Tadalafil beeinflusst nicht die VO2max, die aerobe sowie anaerobe Schwelle in Normoxie |
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Autor: | Di Luigi, L.; Baldari, C.; Pigozzi, F.; Emerenziani, G.P.; Gallotta, M.C.; Iellamo, F.; Ciminelli, E. ; Sgrò, P.; Romanelli, F.; Lenzi, A.; Guidetti, L. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 29 (2008), 2, S. 110-115, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-2007-965131 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU200808002371 |
Quelle: | BISp |
Abstract
Whereas experimental studies showed that in healthy trained subjects, the phosphodiesterase-5 inhibitor (PDE-5i) sildenafil improves exercise capacity in hypoxia and not in normoxia, no studies on the effects of the long half-life PDE-5i tadalafil exist. In order to evaluate whether tadalafil influences functional parameters and performance during a maximal exercise test in normoxia, we studied 14 healthy male athletes in a double-blind cross-over protocol. Each athlete performed two tests on a cycle ergometer, both after placebo or tadalafil (at therapeutic dose: 20 mg) administration. Oxygen consumption (VO2), blood lactate, respiratory exchange ratio, rate of perceived exertion, arterial blood pressure (BP), heart frequency (HR) and oxygen pulse (VO2/HR) were evaluated before exercise, at individual ventilatory and anaerobic thresholds (IVT and IAT), at VO2max and during recovery. Compared to placebo, a single tadalafil administration significantly reduced systolic BP before and after exercise (p < 0.05), decreased VO2/HR at IVT (13.3 ± 1.8 vs. 14.5 ± 2.1 mL/beat; p = 0.03), but did not modify individual VO2max, IVT or IAT. In healthy athletes, 20 mg of tadalafil does not substantially influence physical fitness-related parameters, exercise tolerance and cardiopulmonary responses to maximal exercise in normoxia; it remains to be verified if higher doses/prolonged use influence health and/or sport performance in field conditions. Verf.-Referat