Magnitude- and time-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats
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| Deutscher übersetzter Titel: | Umfangs- und Zeitabhängigkeit der Wirkung von Laufbandbelastung auf die Zellproliferation im Gyrus dentatus von Ratten |
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| Autor: | Kim, Y.-P.; Kim, H.-B.; Jang, M.-H.; Lim, B.-V.; Kim, Y.-J.; Kim, H.; Kim, S.-S.; Kim, E.-H.; Kim, C.-J. |
| Erschienen in: | International journal of sports medicine |
| Veröffentlicht: | 24 (2003), 2, S. 114-117, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
| Sprache: | Englisch |
| ISSN: | 0172-4622, 1439-3964 |
| DOI: | 10.1055/s-2003-38202 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU200410002791 |
| Quelle: | BISp |
Abstract
The effect of treadmill exercise on cell proliferation in the dentate gyrus was studied in Sprague-Dawley rats via 5-bromo-2'-deoxyuridine (BrdU)-specific immunohistochemistry. For studying the dependence of this effect on the magnitude of exercise, animals were divided into the control, light-exercise, moderate-exercise, and severe-exercise groups; different exercise regimens were applied to the groups. To study the temporal dependence of this effect, animals were divided into the control, 1-day-exercise, 3-days-exercise, 7-days-exercise, 14-days-exercise, and 28-days-exercise groups; the regimen used on the light-exercise group was applied to each of the exercise group over the respective number of days. Cell proliferation was most prominent in the light-exercise group (p<0.001) and reached a maximum level after 7 days of exercise (p<0.001). In this study, it was shown that cell proliferation is modulated by the intensity and duration of treadmill exercise. Verf.-Referat