D-amphetamine-induced hydrogen peroxide production in skeletal muscle is modulated by monoamine oxidase inhibition

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Deutscher übersetzter Titel:D-Amphetamin-induzierte Wasserstoffperoxid-Produktion in der Skelettmuskulatur wird durch Monoaminoxidasehemmung (MAO-Hemmung) verändert
Autor:Duarte, José Alberto; Carvalho, F.; Fernandes, E.; Remiao, R.; Bastos, M.L.; Magalhaes, J.; Appell, Hans-Joachim
Erschienen in:International journal of sports medicine
Veröffentlicht:25 (2004), 6, S. 446-449, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Gedruckte Ressource Elektronische Ressource (online)
Sprache:Englisch
ISSN:0172-4622, 1439-3964
DOI:10.1055/s-2004-820937
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Erfassungsnummer:PU200410002749
Quelle:BISp

Abstract des Autors

The aim of this paper was to study the influence of d-amphetamine administration as a sympathomimetic drug on the synthesis of hydrogen peroxide (H2O2) in mouse soleus muscle and to investigate the modulating effects of pargyline, an inhibitor of monoamine oxidase (MAO) in this context. Charles River mice were assigned to four groups: Control, d-amphetamine treated, pargyline treated, and amphetamine + pargyline treated. Their soleus muscles were removed 0, 15, 30, 60, and 120 min after treatment. The amount of hydrogen peroxide formation within the muscles was estimated using an indirect method. The control data showed a continuous production of hydrogen peroxidase. Pargyline administration lead to an initial increase of H2O2 production that later faded below control levels. Administration of amphetamine finally stimulated H2O2 production much above control levels. When combining amphetamine and pargyline treatment, H2O2 production was accelerated in the initial phase but dropped to control levels at 30 min. It is concluded that in skeletal muscle MAO is an important source of hydrogen peroxide production triggered by amphetamine administration and that this tissue plays a hitherto not described role in oxidizing circulating biogenic monoamines. Verf.-Referat