Abstract des Autors

It was the aim of the study to analyse the haemostatic system during a high standardized intensive short-term (30 s) exercise (anaerobic Wingate test). Blood samples were taken from 15 male subjects before (t0), and within 2 (t1), 9 (t2) and 30 min (t3) after the test. We found that the partial thromboplastin time was markedly shortened, whereas the prothrombin time increased slightly from t0 to t1 (p<0.002) and remained elevated (t3, p<0.046). Factor VIII increased from t0 to t1 (p<0.001) and remained elevated as well (t3, p<0.001). Fibrin monomers were approximately 15 times higher immediately post-exercise (t1, p<0.001) and continued to be elevated (t3, p<0.004). The tissue plasminogen activator increased by 4 times after exercise (t1, p<0.001) and remained elevated (t3, p<0.002). The d-dimers increased from t0 to t1 (p<0.001) as well and remained elevated (t3, p<0.005). Thrombopoietin concentrations were unchanged, whereas the vascular endothelial growth factor increased immediately post-exercise (t0 to t1, p<0.011 resp. at t2 p<0.019) and returned to the control level at t3 (p < 0.878). In conclusion, it was found that prothrombotic markers and, even more pronounced, those of the fibrinolytic system were increased. The study provides evidence that due to intensive short-term exercise the balance of the haemostatic system is shifted to a higher equilibrium. Theoretically, the data show that in the case of a subject with risk factors such as impaired fibrinolysis, unfavourable conditions cannot be excluded. Verf.-Referat