Combination of estrogen replacement and exercise protects against HDL oxidation in post-menopausal women
Deutscher übersetzter Titel: | Kombination von Östrogen-Substitution und körperliche Belastung schützt gegen HDL-Oxidation bei Frauen in der Postmenopause |
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Autor: | Lawler, J.M.; Hu, Z.; Green, J.S.; Crouse, S.F.; Grandjean, P.W.; Bounds, R.G. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 23 (2002), 7, S. 477-483, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-2002-35066 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU200407001936 |
Quelle: | BISp |
Abstract des Autors
The incidence of atherosclerosis and cardiovascular disease (CVD) in women increases following menopause and has been associated with a reduction in circulating estrogen. Increased CVD risk is also perpetuated by sedentary lifestyle. Growing evidence indicates that oxidation of lipoproteins leads to a powerful immune response, disruption of normal lipoprotein function, and deposition of atherosclerotic plaques. For example, once high-density lipoproteins (HDL) are oxidized, they lose the ability to a) participate in reverse transport of cholesterol to the liver, and b) protect low-density lipoproteins (LDL) against oxidation. The purpose of this study was to determine the effects of combining estrogen replacement and exercise upon lipid peroxidation of the HDL fraction (HDL-ox). Blood samples were drawn from 34 post-menopausal women from four groups: women who were not receiving estrogen replacement and who were seden-tary (NSD) (n=9); women who were not receiving estrogen replacement and who were participating in regular exercise (NEX) (n=8); women who were receiving estrogen replacement and who were sedentary (ESD) (n=8); and women who were receiving estrogen replacement and who were participating in regular exercise (EEX) (n=9). Total-HDL cholesterol was significantly higher (p<0.05) in EEX when compared with NEX, NSD, and ESD. HDL-ox was assessed via malondialdehyde (MDA). Mean (± SEM) values for HDL MDA expressed in nM are as follows: NSD = 903.3 ± 118.4; NEX = 1226.7 ± 247.7; ESD = 876.7 ± 116.3; EEX = 537.4 ± 74.8. EEX lipid peroxidation was significantly (p = 0.02) lower than NEX. Lipid peroxidation tended to be lower in EEX than in NSD and ESD (p=0.07). These data indicate that the combination of estrogen replacement and regular exercise in post-menopausal women may be most effective in reducing oxidation of HDL in vivo. Verf.-Referat