Abstract des Autors

We studied the effect of a single-dose non-selective betablocker (propranolol) on circulatory and ventilatory responses and on ventilatory threshold in a graded cycle exercise test in 10 healthy, normotensive male students, in a randomized placebo controlled study. The exercise tests were performed 4 hours after ingestion of the medication. Exercise heart rate and systolic blood pressure were significantly lowered during betablockade in relation to placebo. There was a slight (3%), but non-significant decrease in maximal work load and maximal oxygen uptake during betablockade. Neither was the decrease (7%) in maximal minute ventilation statistically significant. Propranolol had no significant effect on the rate of perceived exertion. Oxygen uptake at the ventilatory threshold did not differ significantly between the betablocker and placebo tests. This data shows that maximal working capacity, at least for an event with relatively short duration, is not markedly limited 4 hours after ingestion of a single-dose of non-selective betablocker in young healthy, physically active men. Verf.-Referat